Panther ID:22573: Difference between revisions

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ECOLI_PHOSMANMUT-MONOMER P24175
ECOLI_PHOSMANMUT-MONOMER P24175


because of positive experimental annotations to HUMAN_ENSG00000013375, MOUSE_MGI:97566, YEAST_S000000784 (PCM1), ECOLI_PHOSGLUCOSAMINEMUT-MONOMER P31120


3) hypoxanthine phosphoribosyltransferase activity (GO:0004422)
Up-propagation to AN204, down-propagation to the following Ref Genome proteins:
because of positive experimental annotations to HUMAN_ENSG00000165704, MOUSE_MGI:96217, RAT_2826, ECOLI_HYPOXANPRIBOSYLTRAN-MONOMER P0A9M2.


because of positive experimental annotations to HUMAN_ENSG00000013375, MOUSE_MGI:97566, YEAST_S000000784 (PCM1), ECOLI_PHOSGLUCOSAMINEMUT-MONOMER P31120


3) NOT phosphoglucomutase activity to the PGM5 clade.
4) NOT phosphoglucomutase activity (GO:0004614) to the PGM5 clade.


Up-propagation to AN9, down-propagation to the following Ref Genome species:
Up-propagation to AN9, down-propagation to the following Ref Genome proteins:


HUMAN_ENSG000000204794
HUMAN_ENSG000000204794

Revision as of 14:12, 28 July 2009

HPRT1, hypoxanthine guanine phosphoribosyltransferase

Cross references:

See SourceForge 1893061 and 1893082.

  • [PPOD Jaccard1673]: not enough experimental annotations (only human protein UniProtKB:P00492 had exp. ann.) in this subsection of the big PANTHER family, so could not do transfer.

Molecular Function

Propagation:

1) phosphoglucomutase activity (GO:0004614)

Up-propagation to common ancestor node AN100, down-propagation to the following Ref Genome proteins:

HUMAN_ENSG00000165434 MOUSE_MGI:1918224 RAT_1584532 RAT_1583226 CHICK_419052 DANRE_ZDB-GENE-041008-205 HUMAN_ENSG00000169299

because of positive experimental annotations to MOUSE_MGI:97564, YEAST_S0000004891 (PGM3), ECOLI_PHOSPHGLUCMU-MONOMER

2) intramolecular transferase activity, phsophotransferases (GO:0016868)

  • cannot do this in PAINT because this is a parent term *

Up-propagation to common ancestor node AN318, down-propagation to the following Ref Genome proteins:

RAT_1305221 CHICK_421841 DANRE_ZDB-GENE-041024-13 CAEEL_WBGene00009006 DROME_FBgn0036298 SCHPO_SPAC13C5.05C SCHPO_SPAC1296.01C ARATH_LOCUS NP_568359 DICDI_DDB_G0281789 ARATH_LOCUS NP_177239 ARATH_LOCUS NP_568350 ECOLI_PHOSMANMUT-MONOMER P24175

because of positive experimental annotations to HUMAN_ENSG00000013375, MOUSE_MGI:97566, YEAST_S000000784 (PCM1), ECOLI_PHOSGLUCOSAMINEMUT-MONOMER P31120

3) hypoxanthine phosphoribosyltransferase activity (GO:0004422) Up-propagation to AN204, down-propagation to the following Ref Genome proteins:

because of positive experimental annotations to HUMAN_ENSG00000165704, MOUSE_MGI:96217, RAT_2826, ECOLI_HYPOXANPRIBOSYLTRAN-MONOMER P0A9M2.


4) NOT phosphoglucomutase activity (GO:0004614) to the PGM5 clade.

Up-propagation to AN9, down-propagation to the following Ref Genome proteins:

HUMAN_ENSG000000204794 RAT_1584213 RAT_1307969 CHICK_427215 DANRE_ENSDARG000000060745

Notes: mouse and human had experimental (IDA) annotations to NOT, but based on protein alignments, can extend the propagation because the active sites have been well characterized. Thus, the alignment of active sites makes the NOT vs. the positive annotations clear. See File:GO EUGENE 2009 pipeline1.ppt for details. Just a note about one protein that has a wildtype site for one active site but mutated for the others: XENTR_ENSXETG000000001670 is in this clade but has the "active" active site at about residue 675 TASHN (where the NOTs have TASHC or TASHS). But, this protein has the other mutated active sites (~1100 FDAD, while active sites have FDGD, and ~1325 has FDY while active sites have YDY).



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