Panther ID:22573
HPRT1, hypoxanthine guanine phosphoribosyltransferase
Cross references:
See SourceForge 1893061 and 1893082.
- [PPOD Jaccard1673]: not enough experimental annotations (only human protein UniProtKB:P00492 had exp. ann.) in this subsection of the big PANTHER family, so could not do transfer.
Molecular Function
The three cervevisiae proteins, PGM1, PGM2, and PGM3, the mouse proteins PGM1 and PGM2, and the fly protein Pgm (last one on the graph) all have experimental annotations to phosphoglucomutase activity. However, the mouse PGM5 has a NOT annotation to this activity and the human also has a NOT.
Alignment of active sites makes the NOT vs. the positive annotations clear. See powerpoint for details. Just a note about one protein that has a wildtype site for one active site but mutated for the others: XENTR_ENSXETG000000001670 is in this clade but has the "active" active site at about residue 675 TASHN (where the NOTs have TASHC or TASHS). But, this protein has the other mutated active sites (~1100 FDAD, while active sites have FDGD, and ~1325 has FDY while active sites have YDY)