Phage call August 21st-23rd 2012
Topics for Aug 21-23rd discussion
QUESTIONS FROM BRENLEY
- BM has been annotating phage lambda proteins (see Gene List of Lambda on EW)
- problems I have encountered:
- GO:0043493 viral terminase complex isn't under GO:0044423 virion part or better yet, 0019028 viral capsid
- GO:0019030 icosahedral viral capsid - definition is a bit confusing b/c it says "the subunits are arranged to form an icosahedron, a solid with 20 faces and 12 vertices".
- Is that true always (i.e. pseudo-T3)? But there isn't an icosahedral viral capsid, major subunit... I just ran into this when annotating the major head protein of lambda (gpE). I could annotate to both (GO:0019030 and GO:0098017), but that seems kind of redundant.
- need regulation of DNA integration terms -- GO:0015074 DNA integration
QUESTIONS FROM BECKY
- killing by virus of host cells during superinfection exclusion ; GO:0039634
- 1/ Is it ALWAYS a lysogenic virus that kills the host cell in response to a subsequent lytic viral infection?
- PMID: 22398285 suggests that the second virus can be the same or a closely related viral type.
- Do we need a term for SUPERINFECTION EXCLUSION (where a pre-existing virus prevents infection of a host cell by a second virus).