Polyketide synthases: Difference between revisions
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(New page: Originated in [https://sourceforge.net/tracker/?func=detail&atid=440764&aid=1866936&group_id=36855| SF 1866936]) |
Batchelorc (talk | contribs) (added set of molecular function terms) |
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Originated in [https://sourceforge.net/tracker/?func=detail&atid=440764&aid=1866936&group_id=36855| SF 1866936] | Originated in [https://sourceforge.net/tracker/?func=detail&atid=440764&aid=1866936&group_id=36855| SF 1866936] | ||
Examples of multistep polyketide biosynthetic processes. ''To do:'' check that none of these happen in a concerted process (very unlikely). | |||
=== Three malonyl transfers and three decarboxylations === | |||
* benzophenone synthase activity (GO:0047181), EC:2.3.1.151 | |||
* acridone synthase activity (GO:0050635), EC:2.3.1.159 | |||
=== Three malonyl transfers and four decarboxylations === | |||
* naringenin-chalcone synthase activity (GO:0016210), EC:2.3.1.74 | |||
* 6'-deoxychalcone synthase activity (GO:0033808), EC:2.3.1.170 | |||
* pinosylvin synthase activity (GO:0050198), EC:2.3.1.146 | |||
* trihydroxystilbene synthase activity (GO:0050350), EC:2.3.1.95 | |||
* phloroisovalerophenone synthase activity (GO:0050634), EC:2.3.1.156 | |||
* 6-methylsalicylic acid sytnhase activity (GO:0050641), EC:2.3.1.165 | |||
These are actually multistep processes involving three malonyl transfers and four | |||
decarboxylations. The overall details are described in PMID: 11959984. The | |||
reaction specifics for GO:0016210 are in PMID: 10653632, which describes how it's a | |||
succession of malonyl-CoA decarboxylations followed by transfer of the | |||
acetyl group to the polyketide chain. | |||
=== Six malonyl transfers === | |||
* erythronolide synthase activity (GO:0047879), EC:2.3.1.94 | |||
=== Eight malonyl transfers === | |||
* lovastatin nonaketide synthase activity (GO:0050637), EC:2.3.1.161 | |||
the clue here is in the synonym: acyl-CoA:malonyl-CoA C-acyltransferase (decarboxylating, oxoacyl- and enoyl-reducing, thioester-hydrolysing) | |||
=== Uncounted === | |||
* mycocerosate synthase activity (GO:0050111), EC:2.3.1.111 | |||
Revision as of 11:20, 10 January 2008
Originated in SF 1866936
Examples of multistep polyketide biosynthetic processes. To do: check that none of these happen in a concerted process (very unlikely).
Three malonyl transfers and three decarboxylations
- benzophenone synthase activity (GO:0047181), EC:2.3.1.151
- acridone synthase activity (GO:0050635), EC:2.3.1.159
Three malonyl transfers and four decarboxylations
- naringenin-chalcone synthase activity (GO:0016210), EC:2.3.1.74
- 6'-deoxychalcone synthase activity (GO:0033808), EC:2.3.1.170
- pinosylvin synthase activity (GO:0050198), EC:2.3.1.146
- trihydroxystilbene synthase activity (GO:0050350), EC:2.3.1.95
- phloroisovalerophenone synthase activity (GO:0050634), EC:2.3.1.156
- 6-methylsalicylic acid sytnhase activity (GO:0050641), EC:2.3.1.165
These are actually multistep processes involving three malonyl transfers and four decarboxylations. The overall details are described in PMID: 11959984. The reaction specifics for GO:0016210 are in PMID: 10653632, which describes how it's a succession of malonyl-CoA decarboxylations followed by transfer of the acetyl group to the polyketide chain.
Six malonyl transfers
- erythronolide synthase activity (GO:0047879), EC:2.3.1.94
Eight malonyl transfers
- lovastatin nonaketide synthase activity (GO:0050637), EC:2.3.1.161
the clue here is in the synonym: acyl-CoA:malonyl-CoA C-acyltransferase (decarboxylating, oxoacyl- and enoyl-reducing, thioester-hydrolysing)
Uncounted
- mycocerosate synthase activity (GO:0050111), EC:2.3.1.111