Proposal for fate of "transcription" and corresponding regulation terms
There are a couple problems with the term transcription (GO:0006350), and with its three associated regulation terms:
- GO:0006350 transcription
- GO:0045449 regulation of transcription
- GO:0045941 positive regulation of transcription
- GO:0016481 negative regulation of transcription
This page contains the 2 possible options for resolution followed by a detailed discussion of the issues and some supporting data.
Proposal
There are 2 possible ways to go with these terms:
- Merge the transcription terms into the 4 corresponding transcription, DNA-dependent terms (pairs shown below). Since we think that essentially all of the annotations should have been made to the more granular transcription, DNA-dependent terms, we feel this might be the conservative approach with respect to annotations.
- Obsolete the 4 transcription and suggest replacement terms. Since the vast majority of annotations are IEAs, which would be fixed by fixing the mappings rather than by having to manually evaluate each annotation, perhaps the group would prefer to go this way rather than risk inappropriately moving a small number of annotations which should actually be to reverse transcription or transcription, RNA-dependent to the transcription, DNA-dependent term.
Regardless of which option is chosen, we are not planning to create a replacement grouping term to group transcription, DNA-dependent and transcription, RNA-dependent. We feel that the existing term RNA biosynthetic process is sufficient, and unlikely to produce confusion in the way that having a grouping term named transcription has.
Problems
- Transcription (GO:0006350) is defined incorrectly.
- Current definition: The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA.
- As written, the definition is specifically grouping "normal" (DNA-dependent) transcription from DNA templates with reverse transcription, which is actually a type of DNA synthesis which should NOT be grouped with transcription at all. It is also excluding production of RNA transcripts from RNA templates, which is a kind of transcription and which occurs in some viruses.
- Confusing use in annotations
- The term transcription (GO:0006350) is being used for annotations as if it were equivalent to transcription, DNA-dependent (GO:0006351), and similarly for the regulation of transcription terms compared with the regulation of transcription, DNA-dependent terms. This is occurring for thousands of annotations, about 20% of the annotations made to transcription or its child terms (numbers from AmiGO below). David and I have scanned a small subset of these annotations and strongly suspect that almost all of these annotations should have been made to the equivalent transcription, DNA-dependent terms, rather than just to transcription; many might be more appropriate going to the even more specific term for transcription from RNA polymerase II promoter.
- In addition to thousands of annotations to these 4 top level transcription terms, there are over 500 mappings (numbers of dbxref mappings below). These mappings are probably the main source of annotations as the vast majority of annotations to these high level grouping terms are by IEA (annotation counts for "transcription" below). So we will want to consider the fate of the mappings in this decision as well.
Fate of direct child terms of transcription
- already included in proposal
- - GO:0045449 regulation of transcription
- - GO:0045941 positive regulation of transcription
- - GO:0016481 negative regulation of transcription
- These terms should be handled in the same manner as transcription.
- input requested
- - GO:0000988 protein binding transcription factor activity
- - GO:0001071 nucleic acid binding transcription factor activity
- These are both new terms that have been added recently as part of the transcription overhaul. I put these in thinking only of DNA-dependent transcription. However, at the moment, nothing about the names or definitions of these terms distinguishes between DNA-dependent or RNA-dependent processes. If anyone knowledgeable about the RNA-dependent process thinks these functions would be needed for the RNA-dependent process, we can make these general terms and create new terms that are subtypes. If no one speaks up though, I might be inclined to just make these terms specific to DNA-dependent transcription since I know almost nothing about RNA-dependent transcription.
- cross product relationships to be changed
- - GO:0034401 regulation of transcription by chromatin organization
- This term has transcription as part of cross product definition, but you have to have DNA to have chromatin, so this relationship seems like it would be more accurately made to transcription, DNA-dependent
- new parentage needed
- - GO:0019083 viral transcription
- Similarly to transcription, DNA-dependent, we think that RNA biosynthetic process would be a sufficient is_a parent for this term. It is not currently a parent, so it would need to be added when transcription is removed.
- no change needed
- - GO:0006351 transcription, DNA-dependent
- This already has an additional is_a parent of RNA biosynthetic process. We feel this is sufficient.
- to be dealt with separately
- - GO:0006410 transcription, RNA-dependent
- - GO:0032199 transcription involved in RNA-mediated transposition
-Karen & David
Supporting Information
transcription & transcription, DNA-dependent term pairs
GO:0006350 transcription => GO:0006351 transcription, DNA-dependent GO:0045449 regulation of transcription => GO:0006355 regulation of transcription, DNA-dependent GO:0045941 positive regulation of transcription => GO:0045893 positive regulation of transcription, DNA-dependent GO:0016481 negative regulation of transcription => GO:0045892 negative regulation of transcription, DNA-dependent
Counts for dbxref mappings to these terms
# of dbxrefs GO term name *225 transcription 43 transcription, DNA-dependent *231 regulation of transcription 708 regulation of transcription, DNA-dependent * 71 positive regulation of transcription 8 positive regulation of transcription, DNA-dependent * 57 negative regulation of transcription 19 negative regulation of transcription, DNA-dependent * mappings which need to be changed
Gene product Annotation counts from AmiGO
GO:0006350 : transcription [28093 gene products] - GO:0006351 : transcription, DNA-dependent [21637 gene products] - GO:0006410 : transcription, RNA-dependent [79 gene products] - GO:0019083 : viral transcription [265 gene products] GO:0045449 : regulation of transcription [25298 gene products] - GO:0006355 : regulation of transcription, DNA-dependent [19684 gene products] - GO:0046782 : regulation of viral transcription [80 gene products] GO:0045941 : positive regulation of transcription [3897 gene products] - GO:0045893 : positive regulation of transcription, DNA-dependent [3099 gene products] - GO:0050434 : positive regulation of viral transcription [58 gene products] GO:0016481 : negative regulation of transcription [4008 gene products] - GO:0075182 : negative regulation of symbiont transcription in response to host [1 gene product] - GO:0045892 : negative regulation of transcription, DNA-dependent [2852 gene products] - GO:0032897 : negative regulation of viral transcription [25 gene products]
Annotation counts for terms by Source and Evidence code
counts from 2-17-2011
transcription
GO:0006350 transcription AspGD IEA 2 GO:0006350 transcription AspGD IMP 4 GO:0006350 transcription AspGD ISA 1 GO:0006350 transcription CGD IEA 6 GO:0006350 transcription dictyBase IC 1 GO:0006350 transcription dictyBase IEA 29 GO:0006350 transcription dictyBase ISS 1 GO:0006350 transcription EcoCyc IDA 11 GO:0006350 transcription EcoCyc IEA 470 GO:0006350 transcription EcoCyc IEP 17 GO:0006350 transcription EcoCyc IGI 3 GO:0006350 transcription EcoCyc IMP 11 GO:0006350 transcription EcoCyc ISS 53 GO:0006350 transcription EcoCyc RCA 1 GO:0006350 transcription Ensembl IEA 24 GO:0006350 transcription FB IDA 7 GO:0006350 transcription FB IEA 11 GO:0006350 transcription FB IEP 2 GO:0006350 transcription FB IMP 3 GO:0006350 transcription FB ISS 13 GO:0006350 transcription FB NAS 8 GO:0006350 transcription FB TAS 4 GO:0006350 transcription GeneDB_Pfalciparum ISS 1 GO:0006350 transcription GeneDB_Spombe IEA 3 GO:0006350 transcription GeneDB_Spombe ISS 5 GO:0006350 transcription GeneDB_Spombe NAS 1 GO:0006350 transcription GeneDB_Tbrucei IDA 1 GO:0006350 transcription GeneDB_Tbrucei ISS 13 GO:0006350 transcription GR_protein IC 1 GO:0006350 transcription GR_protein RCA 3 GO:0006350 transcription JCVI_CMR ISS 54 GO:0006350 transcription MGI IDA 4 GO:0006350 transcription MGI IEA 1594 GO:0006350 transcription MGI IGI 1 GO:0006350 transcription MGI IMP 3 GO:0006350 transcription MGI IPI 1 GO:0006350 transcription MGI ISA 1 GO:0006350 transcription MGI ISO 5 GO:0006350 transcription MGI ISS 1 GO:0006350 transcription MGI NAS 2 GO:0006350 transcription MGI TAS 6 GO:0006350 transcription NCBI ISS 2 GO:0006350 transcription PDB IEA 2653 GO:0006350 transcription PseudoCAP RCA 6 GO:0006350 transcription RefSeq IEA 22 GO:0006350 transcription RGD IEA 43 GO:0006350 transcription RGD ISO 13 GO:0006350 transcription RGD ISS 1 GO:0006350 transcription SGD IDA 6 GO:0006350 transcription SGD IEA 574 GO:0006350 transcription SGD IGI 6 GO:0006350 transcription SGD IMP 8 GO:0006350 transcription SGD IPI 8 GO:0006350 transcription SGD ISA 1 GO:0006350 transcription SGD ISS 3 GO:0006350 transcription SGD RCA 2 GO:0006350 transcription SGD TAS 4 GO:0006350 transcription SGN IEP 1 GO:0006350 transcription TAIR IEA 57 GO:0006350 transcription TAIR ISS 42 GO:0006350 transcription TIGR_CMR ISS 71 GO:0006350 transcription UniProtKB IDA 11 GO:0006350 transcription UniProtKB IEA 467041 GO:0006350 transcription UniProtKB ISS 7 GO:0006350 transcription UniProtKB NAS 7 GO:0006350 transcription UniProtKB TAS 204 GO:0006350 transcription WB IDA 1 GO:0006350 transcription WB IEA 30 GO:0006350 transcription WB IMP 1 GO:0006350 transcription ZFIN IEA 592
regulation of transcription
GO:0045449 regulation of transcription ASAP IMP 1 GO:0045449 regulation of transcription AspGD IEA 5 GO:0045449 regulation of transcription AspGD IMP 3 GO:0045449 regulation of transcription AspGD ISS 2 GO:0045449 regulation of transcription CGD IEA 9 GO:0045449 regulation of transcription CGD IMP 4 GO:0045449 regulation of transcription CGD ISS 1 GO:0045449 regulation of transcription CGD TAS 1 GO:0045449 regulation of transcription dictyBase IEA 25 GO:0045449 regulation of transcription dictyBase IMP 2 GO:0045449 regulation of transcription dictyBase ISS 7 GO:0045449 regulation of transcription EcoCyc IEA 174 GO:0045449 regulation of transcription Ensembl IEA 91 GO:0045449 regulation of transcription FB IDA 13 GO:0045449 regulation of transcription FB IEA 56 GO:0045449 regulation of transcription FB IGI 1 GO:0045449 regulation of transcription FB IMP 20 GO:0045449 regulation of transcription FB ISS 81 GO:0045449 regulation of transcription FB NAS 31 GO:0045449 regulation of transcription FB TAS 13 GO:0045449 regulation of transcription GeneDB_Spombe IDA 3 GO:0045449 regulation of transcription GeneDB_Spombe IEA 4 GO:0045449 regulation of transcription GeneDB_Spombe IMP 1 GO:0045449 regulation of transcription GeneDB_Spombe ISS 33 GO:0045449 regulation of transcription GeneDB_Spombe NAS 3 GO:0045449 regulation of transcription GeneDB_Spombe RCA 1 GO:0045449 regulation of transcription GeneDB_Spombe TAS 6 GO:0045449 regulation of transcription GR_protein IC 304 GO:0045449 regulation of transcription GR_protein IDA 1 GO:0045449 regulation of transcription GR_protein ISS 1 GO:0045449 regulation of transcription GR_protein RCA 18 GO:0045449 regulation of transcription JCVI_CMR IDA 2 GO:0045449 regulation of transcription JCVI_CMR IMP 2 GO:0045449 regulation of transcription JCVI_CMR ISS 57 GO:0045449 regulation of transcription MGI IDA 48 GO:0045449 regulation of transcription MGI IEA 1925 GO:0045449 regulation of transcription MGI IGI 6 GO:0045449 regulation of transcription MGI IMP 17 GO:0045449 regulation of transcription MGI IPI 1 GO:0045449 regulation of transcription MGI ISA 4 GO:0045449 regulation of transcription MGI ISO 39 GO:0045449 regulation of transcription MGI ISS 4 GO:0045449 regulation of transcription MGI NAS 3 GO:0045449 regulation of transcription MGI TAS 10 GO:0045449 regulation of transcription PDB IDA 12 GO:0045449 regulation of transcription PDB IEA 2737 GO:0045449 regulation of transcription PDB IGI 12 GO:0045449 regulation of transcription PDB IMP 21 GO:0045449 regulation of transcription PseudoCAP IDA 4 GO:0045449 regulation of transcription PseudoCAP ISS 2 GO:0045449 regulation of transcription PseudoCAP RCA 13 GO:0045449 regulation of transcription RefSeq IEA 61 GO:0045449 regulation of transcription RGD IDA 5 GO:0045449 regulation of transcription RGD IEA 332 GO:0045449 regulation of transcription RGD IMP 1 GO:0045449 regulation of transcription RGD ISO 90 GO:0045449 regulation of transcription RGD ISS 8 GO:0045449 regulation of transcription RGD NAS 2 GO:0045449 regulation of transcription RGD TAS 4 GO:0045449 regulation of transcription SGD IC 1 GO:0045449 regulation of transcription SGD IDA 2 GO:0045449 regulation of transcription SGD IEA 524 GO:0045449 regulation of transcription SGD IEP 1 GO:0045449 regulation of transcription SGD IGI 1 GO:0045449 regulation of transcription SGD IMP 15 GO:0045449 regulation of transcription SGD IPI 1 GO:0045449 regulation of transcription SGD TAS 2 GO:0045449 regulation of transcription TAIR IDA 6 GO:0045449 regulation of transcription TAIR IEA 224 GO:0045449 regulation of transcription TAIR IEP 3 GO:0045449 regulation of transcription TAIR IGI 3 GO:0045449 regulation of transcription TAIR IMP 9 GO:0045449 regulation of transcription TAIR ISS 2 GO:0045449 regulation of transcription TAIR TAS 529 GO:0045449 regulation of transcription TIGR_CMR ISS 41 GO:0045449 regulation of transcription UniProt IMP 2 GO:0045449 regulation of transcription UniProtKB IDA 52 GO:0045449 regulation of transcription UniProtKB IEA 471085 GO:0045449 regulation of transcription UniProtKB IGI 2 GO:0045449 regulation of transcription UniProtKB IMP 21 GO:0045449 regulation of transcription UniProtKB ISS 108 GO:0045449 regulation of transcription UniProtKB NAS 17 GO:0045449 regulation of transcription UniProtKB TAS 5 GO:0045449 regulation of transcription WB IC 1 GO:0045449 regulation of transcription WB IDA 2 GO:0045449 regulation of transcription WB IEA 193 GO:0045449 regulation of transcription WB IEP 2 GO:0045449 regulation of transcription WB ISS 5 GO:0045449 regulation of transcription WB TAS 7 GO:0045449 regulation of transcription ZFIN IDA 9 GO:0045449 regulation of transcription ZFIN IEA 1193 GO:0045449 regulation of transcription ZFIN IGI 2 GO:0045449 regulation of transcription ZFIN IMP 5 GO:0045449 regulation of transcription ZFIN ISS 2
positive regulation of transcription
GO:0045941 positive regulation of transcription ASAP IMP 2 GO:0045941 positive regulation of transcription ASAP ISA 2 GO:0045941 positive regulation of transcription AspGD IDA 1 GO:0045941 positive regulation of transcription AspGD IEA 1 GO:0045941 positive regulation of transcription AspGD IMP 2 GO:0045941 positive regulation of transcription CGD IDA 1 GO:0045941 positive regulation of transcription CGD IEA 1 GO:0045941 positive regulation of transcription CGD IMP 1 GO:0045941 positive regulation of transcription CGD ISS 1 GO:0045941 positive regulation of transcription dictyBase IEA 2 GO:0045941 positive regulation of transcription dictyBase IMP 2 GO:0045941 positive regulation of transcription dictyBase ISS 1 GO:0045941 positive regulation of transcription EcoCyc IEA 6 GO:0045941 positive regulation of transcription EcoCyc IMP 1 GO:0045941 positive regulation of transcription FB IDA 4 GO:0045941 positive regulation of transcription FB IEA 3 GO:0045941 positive regulation of transcription FB IGI 1 GO:0045941 positive regulation of transcription FB IMP 15 GO:0045941 positive regulation of transcription FB ISS 4 GO:0045941 positive regulation of transcription FB NAS 1 GO:0045941 positive regulation of transcription FB TAS 7 GO:0045941 positive regulation of transcription GeneDB_Spombe IDA 2 GO:0045941 positive regulation of transcription GeneDB_Spombe IEA 4 GO:0045941 positive regulation of transcription GeneDB_Spombe IGI 1 GO:0045941 positive regulation of transcription GeneDB_Spombe ISS 4 GO:0045941 positive regulation of transcription JCVI_CMR ISS 6 GO:0045941 positive regulation of transcription MGI IC 1 GO:0045941 positive regulation of transcription MGI IDA 128 GO:0045941 positive regulation of transcription MGI IEA 7 GO:0045941 positive regulation of transcription MGI IGI 6 GO:0045941 positive regulation of transcription MGI IMP 26 GO:0045941 positive regulation of transcription MGI IPI 3 GO:0045941 positive regulation of transcription MGI ISA 6 GO:0045941 positive regulation of transcription MGI ISO 137 GO:0045941 positive regulation of transcription MGI ISS 25 GO:0045941 positive regulation of transcription MGI TAS 14 GO:0045941 positive regulation of transcription PDB IDA 17 GO:0045941 positive regulation of transcription PDB IEA 60 GO:0045941 positive regulation of transcription PDB IGI 2 GO:0045941 positive regulation of transcription RefSeq IEA 1 GO:0045941 positive regulation of transcription RGD IDA 20 GO:0045941 positive regulation of transcription RGD IEA 21 GO:0045941 positive regulation of transcription RGD IEP 2 GO:0045941 positive regulation of transcription RGD IMP 14 GO:0045941 positive regulation of transcription RGD ISO 209 GO:0045941 positive regulation of transcription RGD ISS 17 GO:0045941 positive regulation of transcription RGD TAS 1 GO:0045941 positive regulation of transcription SGD IDA 3 GO:0045941 positive regulation of transcription SGD IEA 3 GO:0045941 positive regulation of transcription SGD IGI 1 GO:0045941 positive regulation of transcription SGD IMP 4 GO:0045941 positive regulation of transcription SGD IPI 2 GO:0045941 positive regulation of transcription SGD RCA 37 GO:0045941 positive regulation of transcription TAIR IDA 19 GO:0045941 positive regulation of transcription TAIR IEA 6 GO:0045941 positive regulation of transcription TAIR IEP 6 GO:0045941 positive regulation of transcription TAIR IGI 3 GO:0045941 positive regulation of transcription TAIR IMP 4 GO:0045941 positive regulation of transcription TAIR IPI 1 GO:0045941 positive regulation of transcription TAIR ISS 1 GO:0045941 positive regulation of transcription TAIR TAS 6 GO:0045941 positive regulation of transcription TIGR_CMR ISS 1 GO:0045941 positive regulation of transcription UniProt IDA 1 GO:0045941 positive regulation of transcription UniProt IMP 3 GO:0045941 positive regulation of transcription UniProtKB IDA 138 GO:0045941 positive regulation of transcription UniProtKB IEA 5256 GO:0045941 positive regulation of transcription UniProtKB IGI 3 GO:0045941 positive regulation of transcription UniProtKB IMP 27 GO:0045941 positive regulation of transcription UniProtKB ISS 202 GO:0045941 positive regulation of transcription UniProtKB NAS 7 GO:0045941 positive regulation of transcription UniProtKB TAS 10 GO:0045941 positive regulation of transcription WB IDA 1 GO:0045941 positive regulation of transcription WB IEA 1 GO:0045941 positive regulation of transcription WB IMP 1 GO:0045941 positive regulation of transcription ZFIN IDA 4 GO:0045941 positive regulation of transcription ZFIN IEA 17 GO:0045941 positive regulation of transcription ZFIN IGI 4 GO:0045941 positive regulation of transcription ZFIN IMP 8 GO:0045941 positive regulation of transcription ZFIN IPI 5 GO:0045941 positive regulation of transcription ZFIN NAS 1
negative regulation of transcription
GO:0016481 negative regulation of transcription ASAP IDA 1 GO:0016481 negative regulation of transcription ASAP IMP 1 GO:0016481 negative regulation of transcription ASAP ISA 1 GO:0016481 negative regulation of transcription AspGD IEA 1 GO:0016481 negative regulation of transcription AspGD IMP 3 GO:0016481 negative regulation of transcription CGD IDA 1 GO:0016481 negative regulation of transcription CGD IGI 1 GO:0016481 negative regulation of transcription CGD IMP 9 GO:0016481 negative regulation of transcription CGD ISS 1 GO:0016481 negative regulation of transcription dictyBase IEA 1 GO:0016481 negative regulation of transcription dictyBase ISS 1 GO:0016481 negative regulation of transcription EcoCyc IDA 2 GO:0016481 negative regulation of transcription EcoCyc IEA 2 GO:0016481 negative regulation of transcription EcoCyc IMP 1 GO:0016481 negative regulation of transcription Ensembl IEA 3 GO:0016481 negative regulation of transcription FB IDA 18 GO:0016481 negative regulation of transcription FB IEA 2 GO:0016481 negative regulation of transcription FB IEP 2 GO:0016481 negative regulation of transcription FB IGI 4 GO:0016481 negative regulation of transcription FB IMP 10 GO:0016481 negative regulation of transcription FB ISS 3 GO:0016481 negative regulation of transcription FB NAS 14 GO:0016481 negative regulation of transcription FB TAS 8 GO:0016481 negative regulation of transcription GeneDB_Spombe IMP 1 GO:0016481 negative regulation of transcription GeneDB_Spombe ISS 5 GO:0016481 negative regulation of transcription GeneDB_Tbrucei ISS 3 GO:0016481 negative regulation of transcription JCVI_CMR ISS 8 GO:0016481 negative regulation of transcription MGI IC 2 GO:0016481 negative regulation of transcription MGI IDA 75 GO:0016481 negative regulation of transcription MGI IEA 6 GO:0016481 negative regulation of transcription MGI IGI 4 GO:0016481 negative regulation of transcription MGI IMP 16 GO:0016481 negative regulation of transcription MGI IPI 1 GO:0016481 negative regulation of transcription MGI ISA 3 GO:0016481 negative regulation of transcription MGI ISO 119 GO:0016481 negative regulation of transcription MGI ISS 42 GO:0016481 negative regulation of transcription MGI NAS 2 GO:0016481 negative regulation of transcription MGI RCA 1 GO:0016481 negative regulation of transcription MGI TAS 6 GO:0016481 negative regulation of transcription PDB IDA 37 GO:0016481 negative regulation of transcription PDB IEA 478 GO:0016481 negative regulation of transcription RefSeq IEA 2 GO:0016481 negative regulation of transcription RGD IDA 14 GO:0016481 negative regulation of transcription RGD IEA 18 GO:0016481 negative regulation of transcription RGD IEP 1 GO:0016481 negative regulation of transcription RGD IMP 13 GO:0016481 negative regulation of transcription RGD ISO 174 GO:0016481 negative regulation of transcription RGD ISS 20 GO:0016481 negative regulation of transcription RGD NAS 1 GO:0016481 negative regulation of transcription RGD TAS 2 GO:0016481 negative regulation of transcription SGD IDA 4 GO:0016481 negative regulation of transcription SGD IEA 2 GO:0016481 negative regulation of transcription SGD IMP 6 GO:0016481 negative regulation of transcription SGD IPI 2 GO:0016481 negative regulation of transcription SGD RCA 31 GO:0016481 negative regulation of transcription TAIR IDA 8 GO:0016481 negative regulation of transcription TAIR IEA 4 GO:0016481 negative regulation of transcription TAIR IEP 8 GO:0016481 negative regulation of transcription TAIR IGI 1 GO:0016481 negative regulation of transcription TAIR IMP 14 GO:0016481 negative regulation of transcription TAIR IPI 2 GO:0016481 negative regulation of transcription TAIR ISS 2 GO:0016481 negative regulation of transcription TAIR TAS 1 GO:0016481 negative regulation of transcription TIGR_CMR ISS 16 GO:0016481 negative regulation of transcription UniProt IDA 1 GO:0016481 negative regulation of transcription UniProt IGI 2 GO:0016481 negative regulation of transcription UniProtKB IC 1 GO:0016481 negative regulation of transcription UniProtKB IDA 116 GO:0016481 negative regulation of transcription UniProtKB IEA 42674 GO:0016481 negative regulation of transcription UniProtKB IMP 27 GO:0016481 negative regulation of transcription UniProtKB ISS 123 GO:0016481 negative regulation of transcription UniProtKB NAS 17 GO:0016481 negative regulation of transcription UniProtKB TAS 1 GO:0016481 negative regulation of transcription WB IDA 2 GO:0016481 negative regulation of transcription WB IEA 2 GO:0016481 negative regulation of transcription WB IMP 2 GO:0016481 negative regulation of transcription WB ISS 1 GO:0016481 negative regulation of transcription WB TAS 3 GO:0016481 negative regulation of transcription ZFIN IDA 5 GO:0016481 negative regulation of transcription ZFIN IEA 8 GO:0016481 negative regulation of transcription ZFIN IGI 2 GO:0016481 negative regulation of transcription ZFIN IMP 2
Subsets that terms are included in
GO:0006350 transcription Candida GO slim GO:0006350 transcription Fission yeast GO slim GO:0006350 transcription Generic GO slim GO:0006350 transcription PIR GO slim GO:0006350 transcription Plant GO slim GO:0006350 transcription Prokaryotic GO subset GO:0006350 transcription Yeast GO slim GO:0016481 negative regulation of transcription Prokaryotic GO subset GO:0045449 regulation of transcription Prokaryotic GO subset GO:0045941 positive regulation of transcription Prokaryotic GO subset