RNA processing

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Revision as of 16:04, 7 May 2007 by Kchris (talk | contribs) (New page: Work from April 9th session: proposed ontology structure: rRNA processing --endonucleolytic cleavages *K ----cleavage of tricistronic rRNA transcript (SSU-5.8S-LSU) *K ------cleavage of...)
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Work from April 9th session:

proposed ontology structure:

rRNA processing --endonucleolytic cleavages *K


cleavage of tricistronic rRNA transcript (SSU-5.8S-LSU) *K


cleavage of 5’ETS *K


cleavage between SSU-rRNA and 5.8S-LSU *K


cleavage between 5.8S and LSU *K


cleavage of tricistronic rRNA transcript (SSU-LSU-5S) *H


cleavage between SSU and LSU *H


cleavage between LSU and 5S *H


cleavage of bicistronic rRNA transcript (SSU-LSU) *K


cleavage between SSU and LSU *K


cleavage of monocistronic primary LSU rRNA transcript *K


cleavage of monocistronic primary SSU rRNA transcript *K

--exonucleolytic trimming

-rRNA modification (existing) *C and below --base modification


pseudouridylation during ribosome biogenesis


templated


non-templated


2’-O-methylation during ribosome biogenesis


templated


non-templated


dimethylation during SSU biogenesis *H


proposed defs:

rRNA modification_The covalent alteration of one or more nucleotides within an rRNA molecule,.

i--rRNA editing_The insertion, deletion or substitution of nucleotide residues within nascent rRNA transcripts to produce rRNA molecules with sequences that differ from those coded genetically. (how to distinguish this from methylation, pseudoU?)

i--rRNA methylation_The posttranscriptional addition of methyl groups to specific nucleotide residues in an rRNA molecule.

i---rRNA 2’-O-methylation _The posttranscriptional addition of a methyl group to the 2'-O atom of a nucleotide residue in an rRNA molecule (check F def for 2’-O-methylation)

i----snoRNA guided rRNA 2’-O-methylation _The posttranscriptional addition of methyl groups to the 2'-O atom of a nucleotide residue in an rRNA molecule using a snoRNA guide. (synonym: templated…???)

i----non-guided rRNA 2’-O-methylation _The posttranscriptional addition of methyl groups to the 2'-O atom of a nucleotide residue in an rRNA molecule without using a guide RNA. (need to rephrase this to avoid a negation of the guided methylation term)

i--rRNA pseudouridine synthesis_The intramolecular conversion of uridine to pseudouridine in an rRNA molecule.

i--- snoRNA guided rRNA pseudouridine synthesis_The intramolecular conversion of uridine to pseudouridine in an rRNA molecule using a snoRNA guide.

i--- non-guided rRNA pseudouridine synthesis _The intramolecular conversion of uridine to pseudouridine with no guide RNA. (need to rephrase this to avoid a negation of the guided pseudouridylation term)