Stress-activated protein kinase signaling cascade ; GO:0031098
Jump to navigation
Jump to search
Return to Signaling Main Page [[1]]
GO TERMS
stress-activated protein kinase signaling cascade ; GO:0031098 --[isa]stress-activated MAPK cascade ; GO:0051403 ----[isa]JNK cascade ; GO:0007254 ----[isa]p38MAPK cascade ; GO:0038066
stress-activated protein kinase signaling cascade ; GO:0031098 A series of molecular signals in which a stress-activated protein kinase (SAPK) cascade relays one or more of the signals. Exact synonym: SAPK signaling pathway
QUESTIONS
- What is the difference between 'stress-activated protein kinase signaling cascade ; GO:0031098' and 'stress-activated MAPK cascade ; GO:0051403'?
- Is SAPK an outdated name? Some people refer to SAPK and JNK synonymously, others use SAPK as a grouping for JNK and p38 types of MAPK. Although these two cascades respond primarily to stress, they can act on other stimuli.
TO_DO
- I am in favour of obsoleting 'stress-activated protein kinase signaling cascade ; GO:0031098' and 'stress-activated MAPK cascade ; GO:0051403'. That way, annotations could be looked at and transferred to the JNK term, where possible.
REFERENCES
Physiological roles of SAPK/JNK signaling pathway. PMID 15496581
Activation of SAPK/JNKs in vitro. PMID 20811976