Difference between revisions of "Taxon-GO Checks and Commentary - Part 1"

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Revision as of 09:28, 1 September 2009

28th August 2009

I am looking through the file of errors that Chris Mungall's checking script has produced. It is called gaf-taxon-gaffes.txt and is in go/scratch/go-taxon.

Here are the things that I have found:

Annotation errors

  • Senescence: Human annotations to the plant senescence (GO:0010149) term. Senescence in plants is the process whereby cells die just before the shedding of an organ, whereas senscence in humans is the more general aging of cells that remain alive in the organism. We may need to make a new term for the human process, or add a synonym to the existing aging (GO:0007568) term. I have written to ask people, as I am not sure how much these processes differ, and whether we need separate terms.
    • 8 manual annotations by BHF-UCL to plant senescence. I have reported this to GOA, and they will liaise with BHF-UCL and send back any terms changes that need to be made.
    • 7 RGD ISO annotatations to the same term. Wrote to Simon Twigger.
    • organ senescence: 2 manual from RGD, 1 manual from MGI, 3 IEA from Ensembl. I have written to Harold Drabkin and Simon Twigger, but Emily will pass on the information to Ensembl later.
  • Lactation: Mammalian reproduction in chickens: There are 6 AgBase ISS annotations to GO:0001553 "luteinization" or GO:0007595 "lactation", which are both mammalian reproductive processes. Written to Fiona McCarthy.
  • phycobilisome: I will come back to phycobilisome GO:0030089 later as it needs some research.

From Emily:

TAXON RULE INCORRECT. (DEF OF GO TERM INCLUDES CYANOBACTERIUM) GO:0030089 "phycobilisome" only_in NCBITaxon:2759 "Eukaryota" :: Swiss-Prot Q54714 cpcB GO:0030089 PMID:14730074 IDA C protein NCBITaxon:1148 20050613 UniProtKB

TAXON RULE INCORRECT. (DEF OF GO TERM INCLUDES CYANOBACTERIUM) GO:0030089 "phycobilisome" only_in NCBITaxon:2759 "Eukaryota" :: Swiss-Prot Q54715 cpcA GO:0030089 PMID:14730074 IDA C protein NCBITaxon:1148 20050613 UniProtKB

TAXON RULE INCORRECT. (DEF OF GO TERM INCLUDES CYANOBACTERIUM) GO:0030089 "phycobilisome" only_in NCBITaxon:2759 "Eukaryota" :: Swiss-Prot Q01951 apcA GO:0030089 PMID:14730074 IDA C protein NCBITaxon:1148 20050613 UniProtKB

  • gastrulation with mouth forming first: 67 WormBase annotations to 'gastrulation with mouth forming first' GO:0001703. All are IEA. The script objects to nematodes being on a term with only_in_taxon Protostomia. I Have written to Kimberly van Auken to ask if this is right.

Reply:

Hi Jen--

Thanks for asking about these annotations.

C. elegans is actually grouped with the protostomes, which means that with
respect to this basic phylogenetic division, their gastrulation is lumped
in the 'mouth forming first' category.

This categorization of gastrulation is probably a bit of an
oversimplification, as it's really the middle, or gut, that forms first in
elegans.  Nonetheless, I imagine we chose GO:0001703 'gastrulation with
mouth forming first' as the GO term for these IMP annotations to be sure
we annotated our genes to the 'protostome' gastrulation term so the
elegans annotations would be annotated to the same term as genes involved
in protostome gastrulation in other species.

Hope that rationale makes sense.

Cheers,
--Kimberly

I have then checked and this is the lineage of C. elegans in NCBI:

cellular organisms; Eukaryota; Fungi/Metazoa group; Metazoa; Eumetazoa; Bilateria; Pseudocoelomata; Nematoda; Chromadorea; Rhabditida; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis

C. elegans doesn't seem to be under Protostomia, so I sent this reply to Kimberly:

Hi Kimberly,

Thanks for getting back to me so swiftly.

How do you mean 'grouped with Protostomes'? It seems not to be under
protostomes in the NCBI classification. Should I be   marking this 
go term as intended for use with protostomes and some other taxonomic grouping as well?
 
Thanks,

Jen 

reply:

Hi Jen,

In the past, I think the prevailing view was that nematodes didn't neatly
fit into either the protostome or deuterostome classification, so they
were kind of off on their own as 'pseudocoelomates'.  More recently,
however,  a newer classification grouped nematodes, along with arthropods,
as Ecdysozoa, a protostome superclade.  This more recent classification is
what we've been following with these annotations.

Cheers,
--Kimberly

I have written to suggest that we come up with a union_of taxon term that covers all the needed groups.

  • nucleus: 14 EcoCyc IEA annotations of E. coli gene products to 'nucleus' GO:0005634. Written to Jim Hu to ask about these.
  • Emily is looking at the file too, and is making notes of the numbers of annotations errors found, and the fixes that she has applied. She is feeding this information back, along with any ontology errors that she finds.


Ontology errors

sensory perception

Sensory perception GO:0007600 seems to be much less granular than its parent GO:0050890 cognition

    • I need a taxon link for neurological system process, which is the ancestor that indicates involvement of the brain. TODO
    • I need to add the cognitive part to the def of sensory perception. DONE

sensory perception
old def:The series of events required for an organism to receive a sensory stimulus, convert it to a molecular signal, and recognize and characterize the signal.

new def: The series of events required for an organism to receive a sensory stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process.

cognition
def: The operation of the mind by which an organism becomes aware of objects of thought or perception; it includes the mental activities associated with thinking, learning, and memory.

nutrient reservoir activity

I have written to Tanya and Donghui about this term, as it has lots of TAIR annotations but an Arthropoda taxon link. I'm hoping they'll be able to shed light on what it means so we can improve the def and correct the taxon link.

GO:0045735
nutrient reservoir activity
def: Functions in the storage of nutritious substrates.
  • Emily has checked the UniProtKB manual annotation lines and has provided comments with CAPS at the beginning of full annotation lines.

Multi-organism process

Emily's comment:

TAXON RULE INCORRECT THIS TERM SHOULD INCLUDE VIRUSES GO:0019064 "viral envelope fusion with host membrane" only_in NCBITaxon:131567 "cellular organisms" :: Swiss-Prot P36334 S GO:0019064 PMID:11162792 TAS P protein NCBITaxon:31631 20030508 UniProtKB

viral envelope fusion with host membrane: How do I stop this term from inheriting the restriction to cellular organisms?

I could make a link for the term that is only_in_taxon viruses, as that is what the terms is for, but it seems as if there is some principle of multi-organism process terms showing here. I wonder if we can solve this using internal cross products? Virus.gif

Photoprotection

Emily's comment:

TAXON RULE INCORRECT GO:0010117 "photoprotection" only_in NCBITaxon:33090 "Viridiplantae" :: Swiss-Prot P83690 P83690 GO:0010117 PMID:22511991 TAS P protein NCBITaxon:105610 20041119 UniProtKB (PMID: 12595737:"Reef-building corals contain fluorescent pigments termed pocilloporins that function by regulating the light environment of coral and acting as a photoprotectant in excessive sunlight.)"

This taxon rule is actually okay, but the definition of the term is very woolly and needs improved. This term was intended for the plant processes, but these are quite diverse, and should really be covered by several terms. There will need to be a new term for the Coral process. There could perhaps be a broad grouping term above all of these, and I think that the annotator assumed that that was what this term was when annotating the coral protein. I have requested a pdf from the library for an article that will enable creation of these terms:

http://arjournals.annualreviews.org/doi/abs/10.1146%2Fannurev.arplant.50.1.333

Euglena

Comments from Emily:

TAXON RULE INCORRECT EUGLENA CONTAIN CHLOROPLASTS AND cytochrome b6f complex GO:0009775 "photosynthetic electron transport in cytochrome b6/f" only_in ID:0000000 "Viridiplantae or Bacteria" :: Swiss-Prot P31480 petB GO:0009775 PMID:12837550 NAS P protein NCBITaxon:3039 20031120 UniProtKB

TAXON RULE INCORRECT EUGELA CONTAIN CHLOROPLASTS GO:0009507 "chloroplast" only_in NCBITaxon:33090 "Viridiplantae" :: Swiss-Prot P83687 PSBP GO:0009507 PMID:12837550 IDA C protein NCBITaxon:3039 20031120 UniProtKB

TAXON RULE INCORRECT EUGELA CONTAIN CHLOROPLASTS GO:0009507 "chloroplast" only_in NCBITaxon:33090 "Viridiplantae" :: Swiss-Prot Q8GZR2 petA GO:0009507 PMID:12837550 IDA C protein NCBITaxon:3039 20031120 UniProtKB

TAXON RULE INCORRECT EUGELA CONTAIN CHLOROPLASTS GO:0009507 "chloroplast" only_in NCBITaxon:33090 "Viridiplantae" :: Swiss-Prot P83688 P83688 GO:0009507 PMID:12837550 IDA C protein NCBITaxon:3039 20031120 UniProtKB

TAXON RULE INCORRECT EUGELA CONTAIN CHLOROPLASTS AND cytochrome b6f complex GO:0009512 "cytochrome b6f complex" only_in JD:0000002 "Viridiplantae or Cyanobacteria" :: Swiss-Prot Q84TU6 petD GO:0009512 PMID:12837550 IDA C protein NCBITaxon:3039 20040507 UniProtKB

TAXON RULE INCORRECT EUGELA CONTAIN CHLOROPLASTS AND cytochrome b6f complex GO:0009512 "cytochrome b6f complex" only_in JD:0000002 "Viridiplantae or Cyanobacteria" :: Swiss-Prot P31480 petB GO:0009512 PMID:12837550 IDA C protein NCBITaxon:3039 20031120 UniProtKB

I am going to need to make changes to the taxon links to take account of Euglena. Apparently it is thought to have been a call that acquired an endosymbiotic green algal cell, and contains chloroplasts similar to those in algae. http://euglena.msu.edu/chloroplast_mito.shtml

Need links to show that chloroplasts are in Viridiplantae or Euglena.

I will do this later, as it may be a big job.

DNA replication

Emily's comment:

TAXON RULE INCORRECT: GO:0006260 "DNA replication" only_in NCBITaxon:131567 "cellular organisms" :: TrEMBL O00529 O00529 GO:0006260 GO_REF:0000029 NAS P protein NCBITaxon:333760 20021106 UniProtKB (ATP-dependent DNA helicase required for initiation of viral DNA replication. It forms a complex with the viral E2 protein. The E1-E2 complex binds to the replication origin which contains binding sites for both proteins)

I discussed this with Jane and we decided to rename DNA replication to be cellular DNA replication and make a new generic parent that would be okay for annotation of viruses. There were whole string of ancestors of DNA replication that were not named or defined as cellular but were logically defined as cellular by their position in the graph. I have renamed all of these to be the cellular version and made generic parents. The before and after graphs are shown below.

Before:

DNA.gif

After:

DNANew.gif


System problems

Taxon hierarchy problems

THIS ORGANISM IS A CHILD OF EUKARYOTA; SOMETHING MISSING IN TAXON HIERARCHY? GO:0009407 "toxin catabolic process" only_in NCBITaxon:131567 "cellular organisms" :: Swiss-Prot P86101 P86101 GO:0009407 PMID:18599388 IDA P protein NCBITaxon:569175 20081222 UniProtKB

Chris responds: Looks like I was using a slightly out of date taxonomy, hence the false positives for bivalves, Candida strains etc. Will try and fix.

UniProt Comments

Comments from Emily:

TAXON RULE INCORRECT (see GO term def:A ribonuclease P complex located in the nucleolus of a eukaryotic cell,and PMID:8918471) GO:0005655 "nucleolar ribonuclease P complex" only_in NCBITaxon:2157 "Archaea" :: Swiss-Prot Q99575 POP1 GO:0005655 PMID:8918471 IDA C protein NCBITaxon:9606 20010813 UniProtKB

FIXED: Multimeric ribonuclease P complex no longer has any taxon link.

TAXON RULE INCORRECT. (annotation to a major plant storage protein) GO:0045735 "nutrient reservoir activity" only_in NCBITaxon:88770 "Panarthropoda" :: Swiss-Prot Q9XHP1 Q9XHP1 GO:0045735 PMID:10606554 NAS F protein NCBITaxon:4182 20051104 UniProtKB

TAXON RULE INCORRECT. (annotation to a major plant storage protein) GO:0045735 "nutrient reservoir activity" only_in NCBITaxon:88770 "Panarthropoda" :: Swiss-Prot Q9SPL3 AMP2-3 GO:0045735 PMID:10571855 NAS F protein NCBITaxon:60698 20060904 UniProtKB

TAXON RULE INCORRECT. (annotation to a major plant storage protein)GO:0045735 "nutrient reservoir activity" only_in NCBITaxon:88770 "Panarthropoda" :: Swiss-Prot Q9XHP0 Q9XHP0 GO:0045735 PMID:10606554 NAS F protein NCBITaxon:4182 20051104 UniProtKB

TAXON RULE INCORRECT. (annotation to a major plant storage protein) GO:0045735 "nutrient reservoir activity" only_in NCBITaxon:88770 "Panarthropoda" :: Swiss-Prot Q39649 Q39649 GO:0045735 PMID:8275099 TAS F protein NCBITaxon:3661 20050516 UniProtKB

FROM SGD ANNOTATION: AND YEAST DO HAVE THESE; PMID: 15103330. SOMETHING MISSING IN TAXON HIERARCHY? GO:0016226 "iron-sulfur cluster assembly" only_in NCBITaxon:131567 "cellular organisms" :: TrEMBL B9W8S4 CD36_08500 GO:0016226 GO_REF:0000024 ISS UniProtKB:P23503 P protein NCBITaxon:573826 20090714 UniProtKB

INAPPROPRIATE ANNOTATION - WRONG AC USED. GO:0007517 "muscle organ development" only_in NCBITaxon:2759 "Eukaryota" :: TrEMBL P84067 tthHB8IM GO:0007517 GO_REF:0000029 NAS P protein NCBITaxon:274 20040707 UniProtKB

INAPPROPRIATE ANNOTATION - WRONG AC USED.GO:0007517 "muscle organ development" only_in NCBITaxon:2759 "Eukaryota" :: TrEMBL P84068 tthHB8IM GO:0007517 GO_REF:0000029 NAS P protein NCBITaxon:274 20040707 UniProtKB

I DON'T KNOW!! ISS FROM FLYBASE ANNOTATION GO:0042331 "phototaxis" only_in NCBITaxon:33090 "Viridiplantae" :: Swiss-Prot Q9GRW7 nonA GO:0042331 GO_REF:0000024 ISS UniProtKB:Q04047 P protein NCBITaxon:7244 20060207 UniProtKB

I DON'T KNOW!! ISS FROM FLYBASE ANNOTATION GO:0042331 "phototaxis" only_in NCBITaxon:33090 "Viridiplantae" :: Swiss-Prot Q9GRX4 nonA GO:0042331 GO_REF:0000024 ISS UniProtKB:Q04047 P protein NCBITaxon:47316 20060207 UniProtKB

GO:0001701 "in utero embryonic development" only_in NCBITaxon:40674 "Mammalia" :: TrEMBL Q6XV80 nbn GO:0001701 GO_REF:0000024 ISS UniProtKB:Q9R207 P protein NCBITaxon:8355 20061204 UniProtKB

INAPPROPRIATE TERM DUE TO HOST/PATHOGEN INTERACTION GO:0001915 "negative regulation of T cell mediated cytotoxicity" only_in NCBITaxon:7742 "Vertebrata" :: TrEMBL Q90VU7 nef GO:0001915 GO_REF:0000024 ISS UniProtKB:P03406 P protein NCBITaxon:11676 20060116 UniProtKB should have been: GO:0052085 negative regulation by symbiont of host T-cell mediated immune response

INAPPROPRIATE ISS) ANNOTATION - TERM DUE TO HOST/PATHOGEN INTERACTION GO:0001915 "negative regulation of T cell mediated cytotoxicity" only_in NCBITaxon:7742 "Vertebrata" :: TrEMBL O40177 nef GO:0001915 GO_REF:0000024 ISS UniProtKB:P03406 P protein NCBITaxon:11676 20060116 UniProtKB

INAPPROPRIATE ANNOTATION - TERM DUE TO HOST/PATHOGEN INTERACTION GO:0001915 "negative regulation of T cell mediated cytotoxicity" only_in NCBITaxon:7742 "Vertebrata" :: TrEMBL Q71VG3 nef GO:0001915 GO_REF:0000024 ISS UniProtKB:P03406 P protein NCBITaxon:11676 20060116 UniProtKB

INAPPROPRIATE ANNOTATION - TERM DUE TO HOST/PATHOGEN INTERACTION GO:0001915 "negative regulation of T cell mediated cytotoxicity" only_in NCBITaxon:7742 "Vertebrata" :: TrEMBL Q9WM24 nef GO:0001915 GO_REF:0000024 ISS UniProtKB:P03406 P protein NCBITaxon:11676 20060116 UniProtKB

INAPPROPRIATE ANNOTATION - TERM DUE TO HOST/PATHOGEN INTERACTION GO:0001915 "negative regulation of T cell mediated cytotoxicity" only_in NCBITaxon:7742 "Vertebrata" :: TrEMBL Q9WLM4 nef GO:0001915 GO_REF:0000024 ISS UniProtKB:P03406 P protein NCBITaxon:11676 20060116 UniProtKB

INAPPROPRIATE ANNOTATION - TERM DUE TO HOST/PATHOGEN INTERACTION GO:0001915 "negative regulation of T cell mediated cytotoxicity" only_in NCBITaxon:7742 "Vertebrata" :: Swiss-Prot Q70627 nef GO:0001915 GO_REF:0000024 ISS UniProtKB:P03406 P protein NCBITaxon:82834 20060116 UniProtKB

  • INAPPROPRIATE ANNOTATION - TERM DUE TO HOST/PATHOGEN INTERACTION GO:0001915 "negative regulation of T cell mediated cytotoxicity" only_in NCBITaxon:7742 "Vertebrata" :: Swiss-Prot P03406 nef GO:0001915 PMID:11689886 IDA P protein NCBITaxon:11686 20060113 UniProtKB

INAPPROPRIATE ANNOTATION - TERM DUE TO HOST/PATHOGEN INTERACTION GO:0001915 "negative regulation of T cell mediated cytotoxicity" only_in NCBITaxon:7742 "Vertebrata" :: Swiss-Prot P03404 nef GO:0001915 GO_REF:0000024 ISS UniProtKB:P03406 P protein NCBITaxon:11678 20061106 UniProtKB

INAPPROPRIATE ANNOTATION - TERM DUE TO HOST/PATHOGEN INTERACTION GO:0001915 "negative regulation of T cell mediated cytotoxicity" only_in NCBITaxon:7742 "Vertebrata" :: Swiss-Prot P04324 nef GO:0001915 GO_REF:0000024 ISS UniProtKB:P03406 P protein NCBITaxon:11679 20060116 UniProtKB

INAPPROPRIATE ANNOTATION - TERM DUE TO HOST/PATHOGEN INTERACTION GO:0001915 "negative regulation of T cell mediated cytotoxicity" only_in NCBITaxon:7742 "Vertebrata" :: UniProtKB Q9PXW9 Q9PXW9 GO:0001915 GO_REF:0000024 ISS UniProtKB:P03406 P protein NCBITaxon:11676 20060116 UniProtKB


TAXON RULE INCORRECT GO:0008274 "gamma-tubulin ring complex" only_in NCBITaxon:4751 "Fungi" :: Swiss-Prot Q95K09 TUBGCP5 GO:0008274 PMID:11694571 ISS UniProtKB:Q96RT8 C protein NCBITaxon:9541 20041006 UniProtKB

e.g. this complex exists vertebrates and invertebrates PMID:10854328, PMID:11134080, PMID: 19509060 TAXON RULE INCORRECT GO:0008274 "gamma-tubulin ring complex" only_in NCBITaxon:4751 "Fungi" :: Swiss-Prot Q9GKK8 BRCA1 GO:0008274 PMID:12214252 NAS C protein NCBITaxon:9598 20021218 UniProtKB

GO:0008274 "gamma-tubulin ring complex" only_in NCBITaxon:4751 "Fungi" :: Swiss-Prot Q96RT7 TUBGCP6 GO:0008274 PMID:11694571 IDA C protein NCBITaxon:9606 20021106 UniProtKB

GO:0008274 "gamma-tubulin ring complex" only_in NCBITaxon:4751 "Fungi" :: Swiss-Prot P38398 BRCA1 GO:0008274 PMID:12214252 NAS C protein NCBITaxon:9606 20021023 UniProtKB

GO:0008274 "gamma-tubulin ring complex" only_in NCBITaxon:4751 "Fungi" :: Swiss-Prot Q96RT8 TUBGCP5 GO:0008274 PMID:11694571 IDA C protein NCBITaxon:9606 20021106 UniProtKB

GO:0008274 "gamma-tubulin ring complex" only_in NCBITaxon:4751 "Fungi" :: Swiss-Prot Q9UGJ1 TUBGCP4 GO:0008274 PMID:10562286 NAS C protein NCBITaxon:9606 20021218 UniProtKB

INAPPROPRIATE ANNOTATION; GO TERM DEF IMPROVEMENTS? GO:0007600 "sensory perception" only_in NCBITaxon:2759 "Eukaryota" :: Swiss-Prot Q9AE24 rprY GO:0007600 GO_REF:0000029 NAS P protein NCBITaxon:817 20030605 UniProtKB

INAPPROPRIATE ANNOTATION; GO TERM DEF IMPROVEMENTS? GO:0007600 "sensory perception" only_in NCBITaxon:2759 "Eukaryota" :: Swiss-Prot Q08408 BF3865 GO:0007600 GO_REF:0000029 NAS P protein NCBITaxon:817 20030512 UniProtKB

INAPPROPRIATE ANNOTATION - ISS FROM MOUSE -> FROG GO:0001701 "in utero embryonic development" only_in NCBITaxon:40674 "Mammalia" :: TrEMBL Q6EKW1 NBS1 GO:0001701 GO_REF:0000024 ISS UniProtKB:Q9R207 P protein NCBITaxon:8355 20061204 UniProtKB

MGI (col 15 incorrect) GO:0007424 "open tracheal system development" only_in NCBITaxon:6656 "Arthropoda" :: MGI MGI:2142149 Ano1 GO:0007424 MGI:MGI:3805598|PMID:18585372 IMP P gene NCBITaxon:10090 20080917 UniProtKB

TAXON RULE INCORRECT.GO:0042475 "odontogenesis of dentine-containing tooth" only_in NCBITaxon:33317 "Protostomia" :: MGI MGI:104659 Dll1 GO:0042475 MGI:MGI:1327472|PMID:9882480 NAS P gene NCBITaxon:10090 20021218 UniProtKB

TAXON RULE INCORRECT.GO:0042476 "odontogenesis" only_in NCBITaxon:33317 "Protostomia" :: MGI MGI:1914505 Zfp422 GO:0042476 MGI:MGI:2449683|PMID:12489153 NAS P gene NCBITaxon:10090 20040226 UniProtKB

TAXON RULE INCORRECT.GO:0042476 "odontogenesis" only_in NCBITaxon:33317 "Protostomia" :: RGD 620229 Zfp422 GO:0042476 RGD:14706453 NAS P gene NCBITaxon:10116 20040226 UniProtKB

GO:0042476 "odontogenesis" only_in NCBITaxon:33317 "Protostomia" :: Swiss-Prot P17026 ZNF22 GO:0042476 PMID:14630903 NAS P protein NCBITaxon:9606 20040226 UniProtKB

GO:0042476 "odontogenesis" only_in NCBITaxon:33317 "Protostomia" :: Swiss-Prot Q9NNX1 TUFT1 GO:0042476 PMID:12489194 NAS P protein NCBITaxon:9606 20030115 UniProtKB

GO:0042476 "odontogenesis" only_in NCBITaxon:33317 "Protostomia" :: Swiss-Prot P02818 BGLAP GO:0042476 PMID:11856645 NAS P protein NCBITaxon:9606 20030114 UniProtKB

GO:0042475 "odontogenesis of dentine-containing tooth" only_in NCBITaxon:33317 "Protostomia" :: Swiss-Prot Q12948 FOXC1 GO:0042475 PMID:12614756 IMP P protein NCBITaxon:9606 20061201 UniProtKB

GO:0042476 "odontogenesis" only_in NCBITaxon:33317 "Protostomia" :: Swiss-Prot Q6W2J9 BCOR GO:0042476 PMID:17517692 IMP P protein NCBITaxon:9606 20081114 UniProtKB

GO:0042476 "odontogenesis" only_in NCBITaxon:33317 "Protostomia" :: Swiss-Prot Q9NRM1 ENAM GO:0042476 GO_REF:0000029 NAS P protein NCBITaxon:9606 20030113 UniProtKB

GO:0042476 "odontogenesis" only_in NCBITaxon:33317 "Protostomia" :: Swiss-Prot P08123 COL1A2 GO:0042476 PMID:1740554 NAS P protein NCBITaxon:9606 20080918 UniProtKB

GO:0042476 "odontogenesis" only_in NCBITaxon:33317 "Protostomia" :: Swiss-Prot P07942 LAMB1 GO:0042476 PMID:15894315 IDA P protein NCBITaxon:9606 20060815 UniProtKB

GO:0042475 "odontogenesis of dentine-containing tooth" only_in NCBITaxon:33317 "Protostomia" :: Swiss-Prot P10070 GLI2 GO:0042475 GO_REF:0000024 ISS UniProtKB:Q0VGT2 P protein NCBITaxon:9606 20070125 UniProtKB