Transcription jamboree

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Examples for discussion at electronic Transcription Jamboree

How much evidence is needed to make MF annotations

i) PMID 11486045 - Fig 2 I would like to annotate to the obsolete term GO:0016564 transcription repressor activity. How should this be annotated to the MF ontology with the new terms?


ii) We have GO:0001102 RNA polymerase II activating transcription factor binding and GO:0001103 RNA polymerase II repressing transcription factor binding Should we also have RNA polymerase II activating/repressing transcription factor ACTIVITY?

Annotation to promoter/DNA binding terms

i) PMID:12270142 Based on figs 1 and 2 have annotated to GO:0045944 positive regulation of transcription from RNA polymerase II promoter Based on fig 3 have annotated to GO:2000679 positive regulation of transcription regulatory region DNA binding

Is this correct or are there other terms that should have been used instead?


ii) PMID: 17332325 Is Fig 3 sufficient to support the following annotations?

GO:0000981 sequence-specific DNA binding RNA polymerase II transcription factor activity

GO:0070888 E-box binding