Wnt signaling Pathway (Archived): Difference between revisions
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Secreted signalling proteins, implicated in regulation of cell fate and patterning during embryogenesis. | Secreted signalling proteins, implicated in regulation of cell fate and patterning during embryogenesis. | ||
# frizzled: PTHR11309 | # frizzled: PTHR11309 | ||
According to Panther, there are at least 7 distinct subfamilies. | |||
#* frz1, frz2, frz7 (Q9UP38, Q14332, O75084) | #* frz1, frz2, frz7 (Q9UP38, Q14332, O75084) | ||
#* frz5, frz8 (Q9H461, | #* frz5, frz8 (Q9H461, | ||
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#* frz3 | #* frz3 | ||
#* frz6 (O60353) | #* frz6 (O60353) | ||
Transmembrane proteins that are receptors for the Wnt signaling proteins. | |||
#* SFRP | #* SFRP | ||
Proteins that are related to the frizzled protein family in that they also contain the Wnt-binding site, but SFRP family are secreted and not membrane bound. | |||
#Dishevelled: PTHR10878 | #Dishevelled: PTHR10878 | ||
#* dvl1, dvl2, dvl3 | #* dvl1, dvl2, dvl3 | ||
Cytoplasmic phosphoproteins, role in cytoplasmic signal transcduction of Wnt signaling pathway. | |||
#* dixdc1 | #* dixdc1 | ||
#Axin: PTHR10845:AN318 | #Axin: PTHR10845:AN318 | ||
#* Subfamily of the RGS (Regulators of G-protein signaling) | #* Subfamily of the RGS (Regulators of G-protein signaling) | ||
#* Axin1, axin2 | #* Axin1, axin2 | ||
Cytoplasmic proteins, negative regulator of Wnt signaling pathway? Regulation of beta-catenin stability. | |||
#* LRP: PTHR10529 | #* LRP: PTHR10529 | ||
Probable co-receptor together with Frizzled for Wnt | |||
Rather large family; we probably need to select one or a few subfamilies. | |||
#* beta-catenin: PTHR23315 | #* beta-catenin: PTHR23315 | ||
The subtree to which beta-catenin belongs seems okay | The subtree to which beta-catenin belongs seems okay | ||
Intracellular cytoskeleton, role in structure of adherens junction. |
Revision as of 05:41, 8 June 2010
Source: http://en.wikipedia.org/wiki/Wnt_signaling_pathway
- wnt: PTHR12027: 6 distinct subfamilies
- wnt1, wnt3
- wnt2, wnt5
- wnt4, wnt8, wnt9, wnt11
- wnt6
- wnt7, wnt16
- wnt10
Secreted signalling proteins, implicated in regulation of cell fate and patterning during embryogenesis.
- frizzled: PTHR11309
According to Panther, there are at least 7 distinct subfamilies.
- frz1, frz2, frz7 (Q9UP38, Q14332, O75084)
- frz5, frz8 (Q9H461,
- frz4, frz9, frz10 (Q9ULV1, frz9 ID, Q9ULW2)
- frz3
- frz6 (O60353)
Transmembrane proteins that are receptors for the Wnt signaling proteins.
- SFRP
Proteins that are related to the frizzled protein family in that they also contain the Wnt-binding site, but SFRP family are secreted and not membrane bound.
- Dishevelled: PTHR10878
- dvl1, dvl2, dvl3
Cytoplasmic phosphoproteins, role in cytoplasmic signal transcduction of Wnt signaling pathway.
- dixdc1
- Axin: PTHR10845:AN318
- Subfamily of the RGS (Regulators of G-protein signaling)
- Axin1, axin2
Cytoplasmic proteins, negative regulator of Wnt signaling pathway? Regulation of beta-catenin stability.
- LRP: PTHR10529
Probable co-receptor together with Frizzled for Wnt Rather large family; we probably need to select one or a few subfamilies.
- beta-catenin: PTHR23315
The subtree to which beta-catenin belongs seems okay Intracellular cytoskeleton, role in structure of adherens junction.