Wnt signaling Pathway (Archived): Difference between revisions
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[[image:220px-WNTPathway.png |right| Wnt receptor]] | [[image:220px-WNTPathway.png |right| Wnt receptor]] | ||
==Project leaders: Varsha Khodiyar, Suzi Lewis== | |||
==Justification (Impact and significance)== | |||
==Range of species in which the pathway if found== | |||
==Species experimentally studied: == | |||
==Possible experts== | |||
make sure to represent mammals, but also : fly, zebra fish, other models?? | |||
==Ontology status== | |||
==Time frame of the project== | |||
* June - August 2010: Primary annotations | |||
* November - December 2010: Tree Annotation | |||
==Background reading== | |||
Source: http://en.wikipedia.org/wiki/Wnt_signaling_pathway | Source: http://en.wikipedia.org/wiki/Wnt_signaling_pathway | ||
==Families to annotate== | |||
#wnt: PTHR12027: 6 distinct subfamilies | #wnt: PTHR12027: 6 distinct subfamilies | ||
#* wnt1, wnt3 | #* wnt1, wnt3 | ||
Revision as of 09:10, 9 June 2010
Project leaders: Varsha Khodiyar, Suzi Lewis
Justification (Impact and significance)
Range of species in which the pathway if found
Species experimentally studied:
Possible experts
make sure to represent mammals, but also : fly, zebra fish, other models??
Ontology status
Time frame of the project
- June - August 2010: Primary annotations
- November - December 2010: Tree Annotation
Background reading
Source: http://en.wikipedia.org/wiki/Wnt_signaling_pathway
Families to annotate
- wnt: PTHR12027: 6 distinct subfamilies
- wnt1, wnt3
- wnt2, wnt5
- wnt4, wnt8, wnt9, wnt11
- wnt6
- wnt7, wnt16
- wnt10
- Secreted signalling proteins, implicated in regulation of cell fate and patterning during embryogenesis.
- frizzled: PTHR11309: 7 distinct subfamilies
- frz1, frz2, frz7 (Q9UP38, Q14332, O75084)
- frz5, frz8 (Q9H461,
- frz4, frz9, frz10 (Q9ULV1, frz9 ID, Q9ULW2)
- frz3
- frz6 (O60353)
- Transmembrane proteins that are receptors for the Wnt signaling proteins.
- SFRP
- Proteins that are related to the frizzled protein family in that they also contain the Wnt-binding site, but SFRP family are secreted and not membrane bound.
- Dishevelled: PTHR10878
- dvl1, dvl2, dvl3
- Cytoplasmic phosphoproteins, role in cytoplasmic signal transduction of Wnt signaling pathway.
- dixdc1
- dvl1, dvl2, dvl3
- Axin: PTHR10845:AN318
- Subfamily of the RGS (Regulators of G-protein signaling)
- Axin1, axin2
- Cytoplasmic proteins, negative regulator of Wnt signaling pathway? Regulation of beta-catenin stability.
- LRP: PTHR10529
- Probable co-receptor together with Frizzled for Wnt
- Rather large family; we probably need to select one or a few subfamilies. Suggest LRP1, LRP5, LRP6.
- beta-catenin: PTHR23315
- The subtree to which beta-catenin belongs seems okay
- Intracellular cytoskeleton, role in structure of adherens junction.