Wnt signaling Pathway (Archived)

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Wnt receptor
Wnt receptor

Source: http://en.wikipedia.org/wiki/Wnt_signaling_pathway

  1. wnt: PTHR12027: 6 distinct subfamilies
    • wnt1, wnt3
    • wnt2, wnt5
    • wnt4, wnt8, wnt9, wnt11
    • wnt6
    • wnt7, wnt16
    • wnt10
  2. frizzled: PTHR11309
    • According to Panther, there are at least 7 distinct subfamilies.
    • frz1, frz2, frz7 (Q9UP38, Q14332, O75084)
    • frz5, frz8 (Q9H461,
    • frz4, frz9, frz10 (Q9ULV1, frz9 ID, Q9ULW2)
    • frz3
    • frz6 (O60353)
    • SFRP
  3. Dishevelled: PTHR10878
    • dvl1, dvl2, dvl3
    • dixdc1
  4. Axin: PTHR10845:AN318
    • Subfamily of the RGS (Regulators of G-protein signaling)
    • Axin1, axin2
  5. LRP: PTHR10529
    • Probable co-receptor together with Frizzled for Wnt
    • Rather large family; we probably need to select one or a few subfamilies.
  6. beta-catenin: PTHR23315

The subtree to which beta-catenin belongs seems okay