Wnt signaling Pathway (Archived)
Source: http://en.wikipedia.org/wiki/Wnt_signaling_pathway
- wnt: PTHR12027: 6 distinct subfamilies
- wnt1, wnt3
- wnt2, wnt5
- wnt4, wnt8, wnt9, wnt11
- wnt6
- wnt7, wnt16
- wnt10
- Secreted signalling proteins, implicated in regulation of cell fate and patterning during embryogenesis.
- frizzled: PTHR11309: 7 distinct subfamilies
- frz1, frz2, frz7 (Q9UP38, Q14332, O75084)
- frz5, frz8 (Q9H461,
- frz4, frz9, frz10 (Q9ULV1, frz9 ID, Q9ULW2)
- frz3
- frz6 (O60353)
- Transmembrane proteins that are receptors for the Wnt signaling proteins.
- SFRP
- Proteins that are related to the frizzled protein family in that they also contain the Wnt-binding site, but SFRP family are secreted and not membrane bound.
- Dishevelled: PTHR10878
- dvl1, dvl2, dvl3
- Cytoplasmic phosphoproteins, role in cytoplasmic signal transcduction of Wnt signaling pathway.
- dixdc1
- Axin: PTHR10845:AN318
- Subfamily of the RGS (Regulators of G-protein signaling)
- Axin1, axin2
- Cytoplasmic proteins, negative regulator of Wnt signaling pathway? Regulation of beta-catenin stability.
- LRP: PTHR10529
- Probable co-receptor together with Frizzled for Wnt
- Rather large family; we probably need to select one or a few subfamilies.
- beta-catenin: PTHR23315
- The subtree to which beta-catenin belongs seems okay
- Intracellular cytoskeleton, role in structure of adherens junction.