Wnt signaling Pathway (Archived)

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Wnt receptor
Wnt receptor

Source: http://en.wikipedia.org/wiki/Wnt_signaling_pathway

  1. wnt: PTHR12027: 6 distinct subfamilies
    • wnt1, wnt3
    • wnt2, wnt5
    • wnt4, wnt8, wnt9, wnt11
    • wnt6
    • wnt7, wnt16
    • wnt10
      • Secreted signalling proteins, implicated in regulation of cell fate and patterning during embryogenesis.
  2. frizzled: PTHR11309: 7 distinct subfamilies
    • frz1, frz2, frz7 (Q9UP38, Q14332, O75084)
    • frz5, frz8 (Q9H461,
    • frz4, frz9, frz10 (Q9ULV1, frz9 ID, Q9ULW2)
    • frz3
    • frz6 (O60353)
      • Transmembrane proteins that are receptors for the Wnt signaling proteins.
    • SFRP
      • Proteins that are related to the frizzled protein family in that they also contain the Wnt-binding site, but SFRP family are secreted and not membrane bound.
  3. Dishevelled: PTHR10878
    • dvl1, dvl2, dvl3
      • Cytoplasmic phosphoproteins, role in cytoplasmic signal transduction of Wnt signaling pathway.
    • dixdc1
  4. Axin: PTHR10845:AN318
    • Subfamily of the RGS (Regulators of G-protein signaling)
    • Axin1, axin2
      • Cytoplasmic proteins, negative regulator of Wnt signaling pathway? Regulation of beta-catenin stability.
    • LRP: PTHR10529
      • Probable co-receptor together with Frizzled for Wnt
      • Rather large family; we probably need to select one or a few subfamilies.
    • beta-catenin: PTHR23315
      • The subtree to which beta-catenin belongs seems okay
      • Intracellular cytoskeleton, role in structure of adherens junction.