Wnt signaling Pathway (Archived)

From GO Wiki
Jump to navigation Jump to search

Project leaders

Varsha Khodiyar, Suzi Lewis

Justification (Impact and significance)

Wnt proteins form a family of highly conserved secreted signaling molecules that regulate cell-to-cell interactions during embryogenesis. Insights into the mechanisms of Wnt action have emerged from several systems: genetics in Drosophila and Caenorhabditis elegans; biochemistry in cell culture and ectopic gene expression in Xenopus embryos. Mutations in Wnt genes or Wnt pathway components lead to specific developmental defects, while various human diseases, including cancer, are caused by abnormal Wnt signaling. As currently understood, Wnt proteins bind to receptors of the Frizzled and LRP families on the cell surface. Through several cytoplasmic relay components, the signal is transduced to beta-catenin, which enters the nucleus and forms a complex with TCF to activate transcription of Wnt target gene (text from [1]

Range of species in which the pathway if found

Species experimentally studied

Possible experts

make sure to represent mammals, but also : fly, zebra fish, other models??

Ontology status

Time frame of the project

  • June - August 2010: Primary annotations
  • November - December 2010: Tree Annotation

Background reading

Wnt receptor
Wnt receptor

Families to annotate

  • Pascale and Paul have reviewed the trees, and there are no obvious problems

Summary: http://amigo-sven.princeton.edu/cgi-bin/amigo/phylotree?mode=index&id=PTHR12027+PTHR11309+PTHR10878+PTHR10845+PTHR10529+PTHR23315

  1. PTHR12027 wnt: 6 distinct subfamilies
    • Secreted signalling proteins, implicated in regulation of cell fate and patterning during embryogenesis.
    • wnt1 (P04628), wnt3 (P56703)
    • wnt2 (P09544), wnt5 (P41221, Q9H1J7)
    • wnt4 (P56705), wnt8 (Q9H1J5, Q93098), wnt9 (O14904, O14905), wnt11 (O96014)
    • wnt6 (Q9Y6F9)
    • wnt7 (O00755, O00755, P56706), wnt16 (Q9UBV4)
    • wnt10 (Q9GZT5, O00744)
  2. PTHR11309 frizzled: 7 distinct subfamilies
    • Transmembrane proteins that are receptors for the Wnt signaling proteins.#* fzd1 (Q9UP38), fzd2 (Q14332), fzd7 (O75084)
    • fzd5 (Q13467), fzd8 (Q9H461)
    • fzd4 (Q9ULV1), fzd9 (O00144), fzd10 (Q9ULW2)
    • fzd3 (Q9NPG1)
    • fzd6 (O60353)
  3. PTHR11309:SF10 SECRETED FRIZZLED (SFRP)
    • Proteins that are related to the frizzled protein family in that they also contain the Wnt-binding site, but SFRP family are secreted and not membrane bound.
      • I think we should include these
    • SFRP1 (Q8N474)
    • SFRP2 (Q96HF1)
    • SFRP4 (Q6FHJ7)
    • SFRP5 (Q5T4F7)
  4. PTHR10878: Dishevelled
    • Cytoplasmic phosphoproteins, role in cytoplasmic signal transduction of Wnt signaling pathway.
    • dvl1 (O14640), dvl2 (O14641), dvl3 (Q92997)
  5. PTHR10878:SF4 DIXIN (DIX DOMAIN-CONTAINING PROTEIN 1)(COILED-COIL PROTEIN DIX1)
    • dixdc1 (? check this?)
  6. PTHR10845:AN318: Axin
    • Subfamily of the RGS (Regulators of G-protein signaling)
    • Axin1 (O15169),
    • axin2 (Q9Y2T1)
    • Cytoplasmic proteins, negative regulator of Wnt signaling pathway? Regulation of beta-catenin stability.
  7. PTHR10529: LRP
    • Probable co-receptor together with Frizzled for Wnt
    • Rather large family; we probably need to select one or a few subfamilies. Suggest LRP5, LRP6.
    • LRP5 (O75197)
    • LRP6 (O75581)
  8. PTHR23315: beta-catenin and the subtree to which beta-catenin belongs seems okay
    • CTNNB1 (P35222)
    • CTNNBIP1 (Q9NSA3)
  9. PTHR12607:SF2 ADENOMATOUS POLYPOSIS COLI PROTEIN
    • Intracellular cytoskeleton, role in structure of adherens junction.
  10. Negative regulator of Wnt signaling, degrades CTNNB1
    • APC (P25054)
    • APC2 (O95996)
  11. PTHR22844:SF10 F-BOX AND WD-40 DOMAIN PROTEIN
    • BTRC (Q9Y297) Mediates the ubiquitination of CTNNB1 and participates in Wnt signaling
    • FBXW11 (Q9UKB1) mediates the ubiquitination of CTNNB1 and participates in Wnt signaling
  12. PTHR13164:SF3 Ubiquitin-mediated degradation of beta-catenin (CTNNB1)
    • CACYBP (Q9HB71)
  13. PTHR12011:SF67 and PTHR25100:SF76 CALCITONIN RECEPTOR
    • CALCR (P30988)
  14. PTHR24347:SF64: long-term potentiation and neurotransmitter release
    • CAMK2A (Q9UQM7)
    • CAMK2B (Q13554)
    • CAMK2D (Q13557)
    • CAMK2G (Q13555)
  15. More suspects and players
  16. PTHR12015:SF30 SMALL INDUCIBLE CYTOKINE A
    • CCL2 P13500
  17. PTHR10177:SF67 G1/S-SPECIFIC CYCLIN-D1
    • CCND1 (P24385)
    • CCND2 (P30279)
    • CCND3 (P30281)
  18. PTHR15273:SF0
    • CER1 (O95813)
  19. PTHR10799:SF46 CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 8 (CHD-8)
    • CHD8 (Q9HCK8) negative regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) activity
  20. PTHR24344:SF26
    • CHEK2 (O96017)
  21. PTHR23056:SF4 CALCINEURIN B SUBUNIT
    • CHP (Q99653)
    • CHP2 (O43745)
  22. PTHR24023:SF127
    • COL1A1 (P02452)
    • COL1A2 (P08123)
  23. PTHR13808:SF0
    • CREBBP (Q92793) part of canonical Wnt pathway
    • EP300 (Q09472)
  24. PTHR11909:SF20
    • CSNK1A1 (P48729) Participates in Wnt signaling
    • CSNK1A1L (Q8N752) Participates in Wnt signaling
    • CSNK1E (P49674) Participates in Wnt signaling
  25. PTHR24054:SF37
    • CSNK2A1 (P68400) Participates in Wnt signaling
    • CSNK2A2 (P19784) Participates in Wnt signaling
  26. PTHR11740:SF0
    • CSNK2B (P67870) Participates in Wnt signaling
  27. PTHR10996:SF11 C-TERMINAL-BINDING PROTEIN 1
    • CTBP1 (Q13363) Canonical Wnt signaling pathway.
    • CTBP2 (P56545)
  28. PTHR11932:SF19 CULLIN 1
    • CUL1 (Q13616) direct ubiquitination of CTNNB1 and participate in Wnt signaling
  29. PTHR13419:SF0
    • CXXC4 (Q9H2H0) negative regulator of the Wnt signaling pathway via its interaction with DVL1
  30. PTHR23213:SF44
    • DAAM1 (Q9Y4D1) mediates Wnt-induced Dvl-Rho complex formation
    • DAAM2 (Q86T65)
  31. PTHR10568:SF4 DICKKOPF-RELATED PROTEIN 1
    • DKK1 (O94907) Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt
    • DKK2 (Q9UBU2) Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt
  32. PTHR12113:SF2
    • DKK4 (Q9UBP4) Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt
  33. PTHR11371:SF7 DEOXYRIBONUCLEASE I
    • DNASE1 (P24855)
  34. PTHR23351 FOS-RELATED ANTIGEN 1
    • FOSL1 (P15407)
  35. PTHR15277
    • FRAT1 (Q92837) Positively regulates the Wnt signaling pathway by stabilizing beta-catenin through the association with GSK-3
    • FRAT2 (O75474) Positively regulates the Wnt signaling pathway by stabilizing beta-catenin through the association with GSK-3.
    • GSK3B (P49841) Participates in the Wnt signaling pathway.
    • ITGB3 (P05106)
    • JUN (P05412) Presenilin action in Notch and Wnt signaling.
    • LEF1 (Q9UJU2) Participates in the Wnt signaling pathway. Activates transcription of target genes in the presence of CTNNB1 and EP300.
    • MAP3K7 O43318 Noncanonical Wnt signaling pathway.
    • MAPK10 P53779
    • MAPK8 P45983
    • MAPK9 P45984
    • MAPT P10636
    • MMP7 P09237
    • MYC P01106 Canonical Wnt signaling pathway.
    • NFAT5 O94916
    • NFATC1 O95644
    • NFATC2 Q13469 Noncanonical Wnt signaling pathway.
    • NFATC3 Q12968
    • NFATC4 Q14934
    • NKD1 Q969G9 Cell autonomous antagonist of the canonical Wnt signaling pathway.
    • NKD2 Q969F2 Cell autonomous antagonist of the canonical Wnt signaling pathway.
    • NLK Q9UBE8 Acts downstream of MAP3K7 and HIPK2 to negatively regulate the canonical Wnt/beta-catenin signaling pathway
    • PDLIM4 P50479
    • PLCB1 Q9NQ66
    • PLCB2 Q00722
    • PLCB3 Q01970
    • PLCB4 Q15147
    • PORCN Q9H237 Modulates the processing of Wnt proteins.
    • PPARD Q03181 Presenilin action in Notch and Wnt signaling.
    • PPP2CA P67775 Regulation of Wnt receptor signaling pathway
    • PPP2CB P62714 Signaling by Wnt.
    • PPP2R1A P30153 regulation of Wnt receptor signaling pathway
    • PPP2R1B P30154 Signaling by Wnt.
    • PPP2R5A Q15172 Signaling by Wnt.
    • PPP2R5B Q15173 Signaling by Wnt.
    • PPP2R5C Q13362 Signaling by Wnt.
    • PPP2R5D Q14738 Canonical Wnt signaling pathway.
    • PPP2R5E Q16537
    • PPP3CA Q08209
    • PPP3CB P16298
    • PPP3CC P48454
    • PPP3R1 P63098
    • PPP3R2 Q96LZ3
    • PRICKLE1 Q96MT3
    • PRICKLE2 Q7Z3G6
    • PRKACA P17612
    • PRKACB P22694
    • PRKACG P22612
    • PRKCA P17252
    • PRKCB P05771
    • PRKCG P05129
    • PRKX P51817
    • PSEN1 P49768 increases the pool of cytoplasmic beta-catenin, thus negatively regulating Wnt signaling
    • PSMA1 P25786 Signaling by Wnt.
    • PSMA2 P25787 Signaling by Wnt.
    • PSMA3 P25788 Signaling by Wnt.
    • PSMA4 P25789 Signaling by Wnt.
    • PSMA5 P28066 Signaling by Wnt.
    • PSMA6 P60900 Signaling by Wnt.
    • PSMA7 O14818 Signaling by Wnt.
    • PSMB1 P20618 Signaling by Wnt.
    • PSMB10 P40306 Signaling by Wnt.
    • PSMB2 P49721 Signaling by Wnt.
    • PSMB3 P49720 Signaling by Wnt.
    • PSMB4 P28070 Signaling by Wnt.
    • PSMB5 P28074 Signaling by Wnt.
    • PSMB6 P28072 Signaling by Wnt.
    • PSMB7 Q99436 Signaling by Wnt.
    • PSMB8 P28062 Signaling by Wnt.
    • PSMB9 P28065 Signaling by Wnt.
    • PSMC1 P62191 Signaling by Wnt.
    • PSMC2 P35998 Signaling by Wnt.
    • PSMC3 P17980 Signaling by Wnt.
    • PSMC4 P43686 Signaling by Wnt.
    • PSMC5 P62195 Signaling by Wnt.
    • PSMC6 P62333 Signaling by Wnt.
    • PSMD1 Q99460 Signaling by Wnt.
    • PSMD10 O75832 Signaling by Wnt.
    • PSMD11 O00231 Signaling by Wnt.
    • PSMD12 O00232 Signaling by Wnt.
    • PSMD13 Q9UNM6 Signaling by Wnt.
    • PSMD14 O00487 Signaling by Wnt.
    • PSMD2 Q13200 Signaling by Wnt.
    • PSMD3 O43242 Signaling by Wnt.
    • PSMD4 P55036 Signaling by Wnt.
    • PSMD5 Q16401 Signaling by Wnt.
    • PSMD6 Q15008 Signaling by Wnt.
    • PSMD7 P51665 Signaling by Wnt.
    • PSMD8 P48556 Signaling by Wnt.
    • PSMD9 O00233 Signaling by Wnt.
    • PSME1 Q06323 Signaling by Wnt.
    • PSME2 Q9UL46 Signaling by Wnt.
    • PSME3 P61289 Signaling by Wnt.
    • PSMF1 Q92530 Signaling by Wnt.
    • PTPN11 Q06124
    • RAC1 P63000
    • RAC2 P15153
    • RAC3 P60763
    • RB1 P06400
    • RBX1 P62877
    • RHOA P61586
    • ROCK1 Q13464
    • ROCK2 O75116
    • RPS27A P62988 Signaling by Wnt.
    • RPS6KA3 Q7Z2J4
    • RUVBL1 Q9Y265
    • SENP2 Q9HC62 down-regulate CTNNB1 levels and thereby modulate the Wnt pathway
    • SKP1 P63208 Signaling by Wnt.
    • SMAD1 Q15797
    • SMAD2 Q15796
    • SMAD3 P84022
    • SMAD4 Q13485 Canonical Wnt signaling pathway.
    • SOS1 Q07889
    • SOX17 Q9H6I2 negative regulation of Wnt receptor signaling pathway through beta-catenin
    • T O15178
    • TBL1X O60907 Wnt receptor signaling pathway through beta-catenin
    • TBL1XR1 Q9BZK7 Wnt receptor signaling pathway through beta-catenin
    • TBL1Y Q9BQ87
    • TCF7 P36402 Wnt signaling pathway
    • TCF7L1 Q9HCS4 Participates in the Wnt signaling pathway.
    • TCF7L2 Q9NQB0 Participates in the Wnt signaling pathway
    • TP53 P04637
    • TRAP1 P24855
    • VANGL1 Q8TAA9
    • VANGL2 Q9ULK5
    • VDR P11473
    • VHL P40337
    • WIF1 Q9Y5W5 Binds to WNT proteins and inhibits their activities.
Retrieved from "https://wiki.geneontology.org/index.php?title=Wnt_signaling_Pathway_(Archived)&oldid=28492"