ZFIN December 2010
CURATORS Doug Howe (Principle GO Curator) Ceri Van Slyke Sridhar Ramachandran Ken Frazer Amy Singer Yvonne Bradford Leyla Bayraktaroglu Barbara Ruef Dave Fashena
DBAs Sierra Moxon Brock Sprunger
TECHNICAL STAFF Xiang Shao Prita Ramachandran Kevin Schaper Nathan Dunn Christian Pich Tom Conlin
As lead GO curator, Doug spends ~0.75FTE on GOC tasks including literature curation, Ref Genome curation and related work, ontology development, meetings, community support, etc. Other curators are primarily involved through GO curation and commit ~0.05-0.10FTE of their time to GO as a routine part of literature curation. Technical staff and DBAs are invoked on an ad hoc basis as needed to support GO activities. This probably averages out to about 0.1FTE total over the course of the year.
Total FTE committed by ZFIN to GOC related activities : ~1.5FTE (0FTE funded by GOC grant)
2. Annotation Progress
|Annotation Type||Dec. 6, 2009||Nov. 14, 2010||Change||% Change|
|Number of genes with at least one GO annotation of any kind||
|Number of Genes with manual annotation||
|Number of genes with IEA annotation||
3. Methods and strategies for annotation (please note % effort on literature curation vs. computational annotation methods)
a. Literature curation:
We generally use ~10% of our curation time making GO annotations from the literature. Close to 0% is spent on computational methods currently.
b. Computational annotation strategies:
We populate our database with ec2go, interpro2go, and spkw2go translations once per month during our UniProt load process. We use no other computational annotation approaches.
c. Priorities for annotation:
Priority is placed on manual curation of the current literature. Doug also curates older papers as required for the Reference Genomes project.
4. Presentations and Publications with substantial GO content
LePendu P, Dou D, Howe, D 2009 Detecting Inconsistencies in the Gene Ontology Using Ontology Databases with Not-gadgets. Lecture Notes in Computer Science 5871:948-965 http://www.springerlink.com/content/e223p72438488242/ DOI: 10.1007/978-3-642-05151-7_15
Su, AI and Howe, DG (2010) Mining the Gene Wiki to Prioritize Literature Curation Efforts. FWCS 2010 http://imageweb.zoo.ox.ac.uk/pub/2010/Proceedings/FWCS2010/01/Paper1.pdf http://esw.w3.org/HCLS/WWW2010/Workshop
5, Other Highlights:
A. Ontology Development Contributions:
Participated in the heart and renal development ontology development meetings. Made regular contributions of SourceForge requesting new terms or ontology corrections.
B. Other Highlights:
-The ZFIN GAF file is now in GAF2.0 format
-ZFIN now has a generic structure in place in our schema and we have begun using it primarily in our curation interface. This will allow us to provide more sophisticated and ontologically aware query results in the future.
-The ability to import externally supplied GAF files into the ZFIN database is in our project que. Completion in the first quarter of 2011 is realistic. This will allow the import of any externally supplied GAF2.0 file, including those from PAINT, UniProt curators, Chris's Function->Process links file and any other external GAF2.0 source.