Acts upstream of

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The acts upstream of gene product to GO term relation is used when the experimental evidence is sufficient to determine the mechanism relating a gene product's activity (MF) to a biological process and that activity occurs before that biological process, is not an integral part of the process, nor does it regulate the process.


c acts upstream of p1 if c enables some f that is involved in p2 and p2 occurs chronologically before p1, is not part of p1, and affects the execution of p1. c is a material entity and f, p1, p2 are processes.

Child Terms

Examples of Usage

  • Wherever possible, curators should choose one of the positive or negative effect child terms.
  • If examples arise where one of the child terms cannot be used, we will include them.

Quality Control Checks

Relations Ontology

acts upstream of

Review Status

Last reviewed: April 12, 2018

Back to: Annotation Relations