Annotation Conf. Call, February 10, 2015
Please send the identifiers for RNA gene products that is being used internally by your MOD for GO annotation. This will provide the initial mappings so that we can then switch over to using the RNACentral IDs. Contact RNA Central using this form - http://rnacentral.org/contact
Demo of CalTech annotation tool
We will use CalTech's annotation tool for our curation consistency exercises. This tool allows us to highlight a sentence and enter specific GO terms/evidence etc. Kimberly will give a demo of how it works. If you want an account in this tool, please put your name down here on this wiki page so Kimberly can send one email to her programmer requesting accounts.
- Aleks (EBI)
- Penelope (EBI)
- Dmitry (MGI)
- David H (MGI)
- Stacia (SGD)
- Tanya (TAIR)
- Donghui (TAIR)
- Leonore (TAIR)
- Doug (ZFIN)
- Sabrina (ZFIN)
- Edith (SGD)
- Midori (PomBase)
- Becky (UCL)
Annotation Consistency Exercise - February 24, 2015
Here is a link to the paper that I've chosen for the first annotation consistency exercise/discussion:
It describes studies on C. elegans bcl-7 (http://www.wormbase.org/species/c_elegans/gene/WBGene00016192) and human BCL7B (http://www.uniprot.org/uniprot/Q9BQE9).
The main thing I'd like to focus on for the annotation exercise is what Biological Process annotations curators make, noting that, at the moment, the all-encompassing Biological Process terms might not yet exist for what is described in the paper. In particular, I'd like to discuss annotating to a process vs. regulation of a process, and the use of annotation extensions to provide more context for the BP terms.
I don't want people to get too hung up on the C. elegans biology, but I've included some links to entries on the anatomy terms and phenotypes described in the paper, in case they're helpful:
- Seam cells
- During larval development, seam cells divide to generate new seam cells renew as well as a number of differentiated cell types (hypodermal/epidermal cell, neuron, glia). They stop renewing once the animals reach adulthood and do not appear to reside in a stem cell-like 'niche'.
- Somatic gonad development
- Egl phenotype
- Pvl phenotype
- Burst phenotype
- Alae morphology phenotype
Note that the paper starts with gross anatomical defects and then progresses to a more detailed characterization of the phenotype. This is fairly typical.