Annotation Extension Relation:in absence of

THIS RELATION IS DEPRECATED

 

==Definition==

Identifies a chemical, gene product or complex in the absence of which an ontology term is observed to apply to the annotated gene product.

==Child terms==

* None.

==Scope of use==

===Domain===

BFO:0000001 ! entity (Biological Process, Molecular Function or Cellular Component)

===Range===

[[ENTITY_UNION:0000005]] ! chemical, gene product, or complex 

=== DEPRECATION WARNING ===

The GO editors have agreed that this relation should be deprecated.  There are two main reasons for this.

* The relation does not extend the meaning of the GO term, as annotation relations are meant to, but instead specifies conditions under which the annotation is true.  This can not be expressed in OWL.  Annotation extensions using this relation will never fold.
* The relation includes a hidden negation.  This is problematic for a number of reasons, the most important of which is that burying negations in otherwise positive relationships can cause serious problems for inference.

==Annotation Extension Usage Examples==

'''Protein localization to component only occurs when substance is absent'''

SCAP (P97260) acts as a SREBP escort protein to localize SREBP from the ER to the Golgi ONLY in sterol-depleted conditions. 


{| class="wikitable" border="1"
|-
! Gene Name (col 2)
! GO ID (col 5)
! Reference (col 6)
! Evidence (col 7)
! Annotation Extension (col 16)
|-
| P97260
|GO:0090110 <span style="color:green">cargo loading into COPII-coated vesicle</span>
| PMID:15899885
| IDA
| 
in_absence_of(CHEBI:15889 <span style="color:green">sterol</span>)
|}

{| class="wikitable" border="1"
|-
! Gene Name (col 2)
! Qualifier (col 4)
! GO ID (col 5)
! Reference (col 6)
! Evidence (col 7)
! Annotation Extension (col 16)
|-
| P97260
| colocalizes_with
| GO:0030127 <span style="color:green">COPII vesicle coat</span>
| PMID:15899885
| IDA
| 
in_absence_of(CHEBI:15889 <span style="color:green">sterol</span>)
|}


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