Causally upstream of, negative effect
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Overview and Scope of Use
- This relation is used in GO-CAMs but not in standard annotation extensions.
- This relation is intended to represent a negative causal effect of one activity on another, where the mechanism is not known.
- The 'causally upstream of, negative effect' relation is used to relate two GO Molecular Functions when:
- the mechanism that relates the upstream activity to the downstream activity is not understood
- the upstream activity occurs before the downstream activity
- the upstream activity has a negative effect on the downstream activity
Annotation Usage Guidelines
- What to capture
- Relationships between molecular functions when a negative effect has been demonstrated but the mechanism is not known.
- What not to capture
- Relationships where the mechanism is known. These should be represented by other relationships.
- There are currently no examples of when this relation would be used between two Molecular Functions, as for causal models, the curator should be able to choose a more specific relation.
- If you have an example of when you'd like to use this relation, please bring the example to a GO Annotation conference call.
Ontology Usage Guidelines
This relation is not used in the ontology.
causally upstream of, negative effect
Last reviewed: February 8, 2023
Reviewed by: Cristina Casals, Marc Feuermann, Pascale Gaudet, David Hill, Patrick Masson, Paul Thomas, Kimberly Van Auken