Causally upstream of, positive effect

From GO Wiki
Jump to navigation Jump to search


  • The 'causally upstream of, positive effect' relation is used to relate two GO Biological Processes or a GO Biological Process to a GO Molecular Function when:
    • the mechanism that relates the upstream process to the downstream process or function is known
    • the activities of the gene products in the upstream process do not directly regulate (i.e. regulate via a direct physical interaction) the activities of the gene products in the downstream process but are otherwise necessary for the downstream gene product to execute its function


  • Needs formal RO definition and review of placement in hierarchy.
  • Proposal: p is causally upstream of, positive effect on q if and only if p precedes q and p and q are linked in a causal chain whereby completion/execution/progression of p increases the frequency, rate or extent of q but not via a direct physical interacction between entities.
  • RO comment: holds between x and y if and only if x is causally upstream of y and the progression of x increases the frequency, rate or extent of y

Child Terms

Examples of Usage

  • Regulation of transcription by a DNA-binding transcription factor activity results in increased levels of target mRNA. Expressed in a GO-CAM model, the transcription process of which the transcription factor activity is a part, has a causally positive effective that acts upstream of the activity of the target. In this case, the transcription factor does not directly regulate the activity of the target, but there is a known, causal process that links the activities of the transcription factor and the product of the transcribed gene.

Quality Control Checks

Relations Ontology

causally upstream of, positive effect

Review Status

Last reviewed: November 26, 2018

Back to: Annotation Relations