Causally upstream of, positive effect
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- The 'causally upstream of, positive effect' relation is used to relate two GO Biological Processes or a GO Biological Process to a GO Molecular Function when:
- the mechanism that relates the upstream process to the downstream process or function is known
- the activities of the gene products in the upstream process do not directly regulate (i.e. regulate via a direct physical interaction) the activities of the gene products in the downstream process but are otherwise necessary for the downstream gene product to execute its function
- Needs formal RO definition and review of placement in hierarchy.
- Proposal: p is causally upstream of, positive effect on q if and only if p precedes q and p and q are linked in a causal chain whereby completion/execution/progression of p increases the frequency, rate or extent of q but not via a direct physical interacction between entities.
- RO comment: holds between x and y if and only if x is causally upstream of y and the progression of x increases the frequency, rate or extent of y
Examples of Usage
- Regulation of transcription by a DNA-binding transcription factor activity results in increased levels of target mRNA. Expressed in a GO-CAM model, the transcription process of which the transcription factor activity is a part, has a causally positive effective that acts upstream of the activity of the target. In this case, the transcription factor does not directly regulate the activity of the target, but there is a known, causal process that links the activities of the transcription factor and the product of the transcribed gene.
- Exemplar GO-CAM model:http://noctua.geneontology.org/editor/graph/gomodel:5a5fc23a00000137
Quality Control Checks
Last reviewed: November 26, 2018