Causally upstream of or within

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Overview and Scope of Use

  • This relation should not be used for annotation, either in standard annotation extensions or in GO-CAMs.
  • The 'causally upstream of of or within' relation is used to relate GO Biological Processes (BP) and/or GO Molecular Functions (MF) when:
    • the mechanism that relates the upstream process (BP or MF) to the downstream process (BP or MF) is not known
    • it is not known whether the activities of the gene products in the upstream process occur before or during the downstream process

Annotation Usage Guidelines

  • If a curator wants to indicate that a process (MF or BP) is causally upstream of another process, they should always be able to choose a more specific sub-relation.


There are no examples because this relation should not be used directly in models. A more precise child should be used instead.

Ontology Usage Guidelines

This relation is not used in the ontology.

Cross Reference to the Relations Ontology (RO)

causally upstream of

Review Status

Last Reviewed: Feb 9, 2023, Pascale Gaudet

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