Causally upstream of or within, negative effect
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Overview and Scope of Use
- This relation is used in standard annotations.
- This relation links an activity to a biological process where the mechanism by which the activity affects the process is not known, but the directionality of the overall effect is negative.
- The 'causally upstream of or within, negative effect' relation links a Molecular Function to a Biological Process when:
- the mechanism that relates the activity to the process is not understood
- the activity has a negative effect on the process
Annotation Usage Guidelines
- What to capture
- Relationships between a molecular function and a biological process when a negative effect has been demonstrated but the mechanism is not known.
- What not to capture
- Relationships where the mechanism is known. These should be represented by causally upstream of, negative effect.
Examples of Usage
Relations Ontology
causally upstream of or within, negative effect
Review Status
Last reviewed: March 16, 2023
Reviewed by: Pascale Gaudet, Kimberly Van Auken