Involved in

Overview

involved in is a relation used between a gene product and a GO Biological Process term when the gene product's Molecular Function plays an integral role in that process.

Examples of Usage

• Damage-induced ubiquitylation of human RNA polymerase II by the ubiquitin ligase Nedd4, but not Cockayne syndrome proteins or BRCA1.
• Nedd4 is an E3 ubiquitin ligase that associates with and ubiquitylates the large subunit of RNA Polymerase II in response to UV-induced DNA damage in human cells. Transcriptional arrest at DNA lesions induced by UV-irridation triggers Nedd4 recruitment and ubiquitylation, and subsequent degradation, of the RNA polymerase II large subunit.
• Nedd4 is thus involved in ubiquitin-dependent protein catabolic process (GO:0006511) that is, in turn, part of a cellular response to DNA damage stimulus (GO:0006974).
• GO-CAM: http://noctua.berkeleybop.org/editor/graph/gomodel:5323da1800000002
  • Inferred GPAD: http://noctua.berkeleybop.org/workbench/annpreview/?model_id=gomodel:5323da1800000002

signaling pathways

• Gene X involved_in signaling pathway P
• Gene X involved_in regulation of some developmental process (controlled by P)

Relations Ontology

involved in

Review Status

Last reviewed: April 13, 2018

Back to: Annotation Relations