NAS discussion

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Email thread


A comment from Emily in one of the other evidence code related threads reminded me that I don't think the group has completely resolved the proposed usage of the with field for the NAS evidence code. Midori brought up a very good point that since authors don't generally make statements about the assumed roles of a gene in terms of GO terms, that it may not be appropriate to use GOids in the with field for NAS statements.

The text of the email discussion is below.


use of with field for NAS

> The Evidence Code Committee discussed the idea of making GO > annotations from Reactome entries. ... What does the full group feel > about the idea of allowing the ID for a database record, when such > exist, in the with field?

Midori (15 Jun 2007):

 I'm all for including annotations based on Reactome entries -- they
 have a well-developed curation system that deeply involves expert
 biologists, so the statements in their records are very reliable.
 I am not in favor of putting the Reactome ID in the with field for
 these annotations, however, because the Reactome entry does not modify
 or supplement the evidence; rather, the entry provides the
 evidence. GO would effectively be using a Recatome record as a source
 of information about a gene product, so it would make much more sense
 to put the Reactome ID in the reference field.
 For the more general database record case, it may be that I don't
 sufficiently understand what might go in a GO_REF (or equivalent), so
 I don't understand the rationale for allowing 'with' for NAS.
 For the case where the author infers one thing from another, using a
 GO ID in 'with' makes more sense, but I think it's not really
 necessary because the author (presumably) hasn't actually made any GO
 annotations, and hasn't stated observations or conclusions in terms
 of, well, GO terms. (Perhaps this will change some day!) Also, note
 that we have expressly disallowed the use of 'with' for NAS, so the
 script would have to be changed if the use of with-for-NAS is agreed.

Karen (9 Sept 2007):

 Regarding the idea of allowing Reactome IDs in the with field, the
 thought was that it provided the specific information about which
 record in Reactome made the statement, but the idea was
 controversial even just with the Evidence Code Committee.
 Regarding the idea of allowing GOids for NAS, I think you bring up a
 good point that this may not make sense since the author has typically
 not stated their statement in terms of a GOid from which an inference
 was made. Allowing this may just be more confusing than helpful,
 especially since deciding which GOid to put in the with field will
 almost always be a curator judgement.
 However, I wasn't one of the proponents of this idea, so those who
 are may wish to defend it.
 In any case, rather than adding yet another usage of the with column
 that is potentially confusing to users, I could personallyjust go
 with not allowing use of the with column at all for NAS.