Non-catalytic Molecular Functions

From GO Wiki
Jump to navigation Jump to search

General considerations

Each gene product should be annotated to at least 1 GO term per GO aspect For MF, we aim for an annotation to a term other than binding or protein binding In the course of MF refactoring we have created several terms to represent non-catalytic functions

Main non-catalytic Molecular Functions

molecular carrier activity (GO:0140104)

Definition: Directly binding to a specific ion or molecule and delivering it either to an acceptor molecule or to a specific location. Note that contrary to a transporter, a carrier moves with the substrate it carries

molecular adaptor activity (GO:0060090)

Definition: The binding activity of a molecule that brings together two or more molecules through a selective, non-covalent, often stoichiometric interaction, permitting those molecules to function in a coordinated way.

molecular sequestering activity (GO:0140313)

Definition: Binding to a specific molecule to prevent it from interacting with other partners or to inhibit its localization to the area of the cell or complex where it is active.

cargo receptor activity (GO:0038024)

Definition: Binding specifically to a substance (cargo) to deliver it to a transport vesicle. Cargo receptors span a membrane (either the plasma membrane or a vesicle membrane), binding simultaneously to cargo molecules and coat adaptors, to efficiently recruit soluble proteins to nascent vesicles. has part molecular adaptor activity part of endocytosis

cargo receptor ligand activity (GO:0140355)

Definition: The activity of a gene product that interacts with a cargo receptor and initiates endocytosis.

signaling receptor activity (GO:0038023)

Definition: Receiving a signal and transmitting it in the cell to initiate a change in cell activity. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response. is_a molecular transducer activity

receptor ligand activity (GO:0048018)

Definition: The activity of a gene product that interacts with a receptor to effect a change in the activity of the receptor. Ligands may be produced by the same, or different, cell that expresses the receptor. Ligands may diffuse extracellularly from their point of origin to the receiving cell, or remain attached to an adjacent cell surface (e.g. Notch ligands). part of signal transduction positively regulates signaling receptor activity

small molecule sensor activity (GO:0140299)

Definition: Binding to a small molecule and eliciting a change in the protein's activity in response to the intracellular level of that small molecule.

protein tag (GO:0031386)

Definition: A molecular function exhibited by a protein that is covalently attached (AKA tagged or conjugated) to another protein where it acts as a marker, recognized by the cellular apparatus to target the tagged protein for some cellular process such as modification, sequestration, transport or degradation.

structural molecule activity (GO:0005198)

Definition: The action of a molecule that contributes to the structural integrity of a complex or its assembly within or outside a cell.

cytoskeletal motor activity (GO:0003774)

Definition: Generation of force resulting in movement, for example along a microfilament or microtubule, or in torque resulting in membrane scission or rotation of a flagellum. The energy required is obtained either from the hydrolysis of a nucleoside triphosphate or by an electrochemical proton gradient (proton-motive force).

protein folding chaperone (GO:0044183)

Definition: Binding to a protein or a protein-containing complex to assist the protein folding process.

RNA folding chaperone (GO:0140691)

Definition: Binding to an RNA or an RNA-containing complex to assist the folding process.

protein-containing complex destabilizing activity (GO:0140776)

Definition: A molecular function that involves direct binding to one of the subunits of a protein-containing complex and promoting the dissociation of one or many subunits. This often happens by changing the conformation of the protein being bound, which decreases its affinity for the rest of the complex.

protein-containing complex stabilizing activity (GO:0140777)

Definition: A molecular function that involves direct binding to one of the subunits of a protein-containing complex, thus preventing an interaction with a factor that would promote dissociation of the complex.

molecular condensate scaffold activity (GO:0140693)

Definition: Binding and bringing together two or more macromolecules in contact, permitting those molecules to organize as a molecular condensate.

ATP-dependent activity (GO:0140657)

Definition: A molecular function characterized by the coupling of ATP hydrolysis to other steps of a reaction mechanism to make the reaction energetically favorable, for example to catalyze a reaction or drive transport against a concentration gradient. has part ATP hydrolysis activity

G protein activity (GO:0003925)

Definition: A molecular function regulator that cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular processes. Intrinsic GTPase activity returns the G protein to its GDP-bound state. The return to the GDP-bound state can be accelerated by the action of a GTPase-activating protein (GAP). is_a GTPase activity

Review Status

Last reviewed: 2022-05-19