Protein and peptidyl amino acid modification / protein processing

From GO Wiki
Jump to navigation Jump to search

The protein amino acid modification and peptidyl amino acid modification terms need to be be revisited and revised. Some of the issues:

  • The difference between peptidyl and protein needs to be cleared up.
  • There is currently no link between 'peptidyl-amino acid modification ; GO:0018193' and the individual types of modification (protein amino acid acylation, protein amino acid deamination etc etc).
  • The difference between protein amino acid modification and protein modification needs to be decided and made clear in the term definitions. E.g. 'protein palmitoleylation ;GO:0045234' vs 'protein amino acid palmitoleylation ; GO:0045235' DONE- terms merged
  • There is currently no generic term for C-terminal protein amino acid modification (the N-terminal equivalent does exist: GO:0031365).


The protein modification terms are currently divided into 4 sections:

    • Type of modification (eg phosphorylation, acylation etc)
    • WHICH amino acid is modified (peptidyl-tyrosine modification)
    • WHERE in the protein the modified amino acid lies (N-terminal protein amino acid modification ; GO:0031365)
    • WHEN the modification occurs (in cases where we know): post translational vs co-translational

Specific changes to do:

  • N-terminal protein amino acid modification ; GO:0031365 probably needs to be moved out from being a child of peptidyl-amino acid modification ; GO:0018193

Related SF items


PROTEIN PROCESSING also needs to be looked at:

At the moment, it's a child of protein maturation, and its definition is restricted to cleavage.Is this too restrictive?

Related SF items