2012 PAINT: Difference between revisions
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* Curation (Pasqual) | * Curation (Pasqual) |
Revision as of 18:48, 13 December 2012
PAINT User Guide: http://wiki.geneontology.org/index.php/PAINT_User_Guide
Preliminary agenda
DAY 1 9am-noon
- Introduction to evolution of gene families and function (Paul)
- PAINT: overview and general utilities (Huaiyu)
DAY 1 1pm-5pm
- Walk though an example: PTHR10003 (CCS)
- The goal is to get everyone familiar with the PAINT tool.
BREAK
- First common example: PTHR19443 (Hexokinase)
- MF annotation
- MF discussion
- CC annotation
- CC discussion
- BP annotation
- BP discussion
DAY 2 9am
- Walk through more complicated examples
- PTHR11537 (Kv channel)
- PTHR11254 (Ubiquitin protein ligase)
- PTHR19384 Nitric oxide synthase
- Excessive downstream processes
- Dinner at Huaiyu's house in Palo Alto. Please plan accordingly.
DAY 3 & DAY 4
- Everyone works on example trees.
- One family each half day, 4 examples total
- Leave an hour at the end of each half day for wrap-up discussion. One participant should present the annotation and lead the discussion.
List of possible examples for the workshop
- Gene duplications
- PTHR19957 (Syntaxin) - similar as above.
- Transcription factors
- PTHR11829 (Transcription factor)
- Very complicated families
- PTHR11256 (bcl-2) - Too many GO terms. How to prioritize?
- ??
- PTHR13697 (Phosphofructokinase)
- PTHR11361? Example of loss of function / stop propagation / add new function without loss
Pascale
- Leukotriene PTHR12050
- PTHR10454 Caspase family
- PMID: 23070001
- PMID: 22949111
- PMID: 22606010
- http://en.wikipedia.org/wiki/Caspase
- PTHR10454 Caspase family
Part of BP discussion:
- Annotations to be cautious about (Pascale)
- Regulation of tyrosine hydroxylase activity
- Activation of transcription factors, including production of downstream proteins (interleukins)
=====================
Action items
- Curation (Pasqual)
- Tracking families curated or being curated
- wiki page
- set up svn locally, so curators will create a folder in svn when a family is being curated
- PAINT tool will add the ability to handle this in svn
- Update user guide (Huaiyu)
- Reopen curated families from svn (checkout from svn, open, curate and upload back to svn)
- svn check in procedure (Paul updated this part)
- Report feedback on issues (Rama)
- ontology issues
- annotation issues
- Biweekly conference calls (Huaiyu will sent reminders)
- Discussion list (Donghui) - Discussion will be on either paint_discuss or go_discuss
- Tracking families curated or being curated
- PAINT tool - Suzi and Brently
Bug track and new feature requests should be done in JIRA. The current ones on google doc should be migrated to JIRA also.