2012 PAINT

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Preliminary agenda

DAY 1 AM

  • Introduction to evolution (Paul)
  • PAINT: overview and general utilities (Huaiyu)


DAY 1 PM

  • Walk though an example: CCS
    • PTHR19443 (Hexokinase) - A classic example of protein families involved in metabolic pathways.
    • PTHR11537 (Kv channela) - A typical example of families of ion channels, transporters and receptors with lots of gene duplications.
    • PTHR19957 (Syntaxin) - similar as above.
    • PTHR11256 (blc-2) - Too many GO terms. How to prioritize?

BREAK

  • First common example (TBD - easy)
    • MF annotation
    • MF discussion


    • CC annotation
    • CC discussion
    • BP annotation
    • BP discussion



DAY 2

  • More common example(s) (TBD - harder)

We need to define types of examples with specific issues:

    • Families where a member has lost a function

WE NEED TO START A TABLE with types


Part of BP discussion:

  • Annotations to be cautious about (Pascale)
    • Regulation of tyrosine hydroxylase activity
    • Activation of transcription factors, including production of downstream proteins (interleukins)



DAY 3 & DAY 4


  • Individual examples & presentations of annotations
    • Everyone starts on MF, CC, BP
  • Discussion on annotation of individual examples