Acts upstream of, negative effect
The acts upstream of gene product, negative effect to GO term relation when the mechanism relating a gene product's activity to a Biological Process is known and the activity occurs before the Biological Process but is neither an integral part of the process, nor an integral part of a process that regulates it, and prevents the process from occuring.
Examples of Usage
- The Cdc42 effectors Ste20, Cla4, and Skm1 down-regulate the expression of genes involved in sterol uptake by a mitogen-activated protein kinase-independent pathway.
- A gene product that binds a 3'-UTR to represses translation of an mRNA 'acts upstream of, negative effect' with respect to the process in which the resulting gene product is involved.
- GP enables mRNA 3'-UTR
- GP acts upstream of, negative effect gene product process
- A gene product that is part of a heterochormatic silencing complex may 'act upstream of, negative effect' for the process is which a transcribed gene is involved.
- Biosynthesis of a molecule that inhibits a downstream process (is sfrp synthesis an example?)
- Post-translational modification of a secreted inhibitor
Last reviewed: March 9, 2018