Acts upstream of or within, negative effect

Overview

The acts upstream of or within, negative effect annotation relation is used when the experimental evidence is not sufficient to determine the mechanism relating a gene product's activity to a biological process. However, the observed experimental outcome indicates that, ultimately, the gene product's activity has a negative effect on the process. Annotations using this relation often come from mutant phenotypes for which further characterization has not been performed, but the authors wish to report the effect that the gene has on a process.

Review Status

Last reviewed: March 9, 2018

Back to: Biological Process