Acts upstream of or within, negative effect: Difference between revisions

Revision as of 10:59, 29 March 2018

Overview

The acts upstream of or within, negative effect annotation relation is used when the experimental evidence is not sufficient to determine the mechanism relating a gene product's activity to a biological process. However, the observed experimental outcome indicates that, ultimately, the gene product's activity has a negative effect on the process. Annotations using this relation often come from mutant phenotypes for which further characterization has not been performed, but the authors wish to report the effect that the gene has on a process.

Definition

Child Terms

Examples of Usage

The zebrafish miR-462/miR-731 cluster is induced under hypoxic stress via hypoxia-inducible factor 1α and functions in cellular adaptations.
- Overexpression of miR-462 and miR-731 represses cell proliferation through blocking cell cycle progress of DNA replication, and induces apoptosis.
- miR-462 'acts upstream of or within, negative effect' cell proliferation (or DNA replication?)

Quality Control Checks

Relations Ontology

acts upstream of or within, negative effect

Review Status

Last reviewed: March 9, 2018

Back to: Biological Process

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 == Examples of Usage ==
 *[https://www.ncbi.nlm.nih.gov/pubmed/?term=26265472 The zebrafish miR-462/miR-731 cluster is induced under hypoxic stress via hypoxia-inducible factor 1α and functions in cellular adaptations.]
-*Overexpression of miR-462 and miR-731 represses cell proliferation through blocking cell cycle progress of DNA replication, and induces apoptosis.
+**Overexpression of miR-462 and miR-731 represses cell proliferation through blocking cell cycle progress of DNA replication, and induces apoptosis.
-*miR-462 'acts upstream of or within, negative effect' cell proliferation (or DNA replication?)
+**miR-462 'acts upstream of or within, negative effect' cell proliferation (or DNA replication?)
 == Quality Control Checks ==