Meeting URL
Agenda
Montreal Meeting, October Wednesday, 17th - Friday, 19th
GO Conference Calls
Tuesdays
- Still will be Tuesdays at 8am PDT
- Proposed meeting schedule:
- 1st Tuesday: Alliance Biological Function
- 2nd Tuesday: GO Consortium
- 3rd Tuesday: Alliance Biological Function/GO-CAM Working Group
- 4th Tuesday: GO-CAM Working Group
- 5th Tuesday: ad hoc, as needed
- One Zoom URL for all - https://stanford.zoom.us/j/976175422
Annotation Discussion
ND Annotations
- Automatic deletion of ND-evidenced annotations
- ND annotations to a root node term are intended to signify that the curator looked at all available evidence and the MF, BP, or CC of a gene/gene product is not known
- GOA proposed to remove ND annotations automatically from their curation database because this was not happening manually
- Note that curators can only update or remove annotations from their respective groups in Protein2GO
- Annotation from only a select set of evidence codes would result in automatic removal of ND annotations
ECO:0000269 (EXP) and its descendants
ECO:0006056 (HTP) and its descendants
ECO:0000250 (ISS) and its descendants
ECO:0000317 (IGC) and its descendants
- Generally agreed that when there is experimental or sequence-based evidence for a more granular annotation, the ND annotation should be removed
- However, 'protein binding' MF annotations are thought of differently by different groups and we need to reach a consensus about how these MF annotations should be considered wrt automatically removing existing MF ND annotations
- Proposal: as part of QC pipeline, alert groups to genes/gene products that have an ND annotation and also an annotation to a more granular term (any evidence code?)
PAINT Annotations
Annotation Review
- 84 open annotation review tickets
- Reminder to check go-annotation tracker tickets where your group has been assigned and finish up where you can
- Questions? Please add questions/comments to the individual tickets
- We can discuss questions on future calls, if needed
Minutes
- On call: David, Edith, George, Harold, Helen, Karen, Kimberly, Laurent-Philippe, Li, Liz, Marie-Claire, Michele, Midori, Pascale, Paul T., Sabrina, Shur-Jen, Seth, Stacia, Suzi A, Suzi L, Tanya, Tom, Stacia, Val
Annotation Discussion
ND Annotations
- We discussed the proposal to automatically remove ND annotations from the GOA database when experimental annotations from another source are available.
- Generally, removing ND annotations once a suitable, more granular term can be assigned to a gene/gene product is standard practice.
- However, not all ND annotations in Protein2GO can be edited by all groups and having a mechanism for dealing with ND annotations that are no longer applicable is desirable.