Annotation Conf. Call 2019-09-10

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October GOC Meeting - Berkeley


  • There have been some glitches with the GOC pipeline.
  • New ontology terms may not be available for use yet.
  • Software team is aware of the issues and working on restoring the pipeline to its regular schedule.

Guidelines: github annotation review tickets

  • Group contacts are listed as 'assignees'
  • Please remove your name from the assignee list when you are finished
  • Some tickets also have lists or tables listing each group - good to add info here, too, but assignee list is most important

GO-CAMs and Annotation Extensions

  • After USC hackathon in June, we formed a small working group to fully articulate the GO-CAM model specifications
  • This will allow for consistent GO-CAM curation using Noctua workbenches, import projects (e.g. Reactome and MOD imports)
  • Will also allow us to move forward with harmonizing AE relations used in GO-CAM and conventional annotation


  • Google spreadsheet for happens during
  • Current recommendations are that 'happens during' is used to define a biological phase or life stage during which a molecular function occurs
  • However, happens_during is not defined in the relations ontology
  • There is a comment, however:
    • X happens_during Y iff: (start(Y) before_or_simultaneous_with start(X)) AND (end(X) before_or_simultaneous_with end(Y))
    • This implies that the start and end of the molecular function and phase are known
    • For things like cell cycle phases or development stages this seems fairly straightforward
  • But what about annotations that referred to a function that 'happens during' a biological process, such as 'response to oxidative stress'?
  • What do we mean when we make these statements?
    • WB had seven MF annotations with 'happens during' extensions that needed review.
      • One used a WBls term, so that was okay.
      • The remaining six used 'response to' terms and in reviewing them, I changed the extension relation to 'part of' the 'response to' term. The MFs were all transcription-related functions that mediated the transcriptional response to unfolded protein, or hypoxia, or heat.
    • (Pascale): If we want to allow happens_during for 'response to' terms, then we should treat them as 'biological phases', and disallow direct annotations. Are there cases where using 'part_of' versus 'happens_during' makes sense ?
  • Updated documentation on 'happens during' usage:

Ontology Updates and Annotation Reviews

Cellular Component

  • 'cell part' and child terms
    • creation of new term ' cellular anatomical entity'

Protein multimerization terms

  • How are the reviews going?
  • Next terms up: protein homodimerization, protein heterodimerization (non-IPI evidence codes)

Transcription terms

  • Any issues or questions here?


  • Present: Colin, David, Dmitry, Dustin, Edith, Giulia, Helen, Harold, Karen, Kimberly, Laurent-Philippe, Michelle, Midori, Pascale, Paul T., Sabrina, Seth, Stacia, Tanya, Petra

GO-CAMs and Annotation Extensions


  • We discussed review and use of 'happens during' as an annotation extension relation for MF terms.
  • Use of 'happens during' with a biological phase of life cycle stage is allowed.
  • Use of 'happens during' with a 'response to x' BP term is still under review.
    • If the MF is an integral part of the 'response to' term, then the curator should update the annotation extension relation to 'part of'.
    • Other 'response to' extensions will need to be examined in more detail to better understand what information we were trying to capture and how it would be modeled in a GO-CAM.
    • PomBase has a number of these annotations and will get back to us on their thoughts.
  • We will also address Barbara's questions about use of 'happens during' on a future call.


  • We will not use SO terms with the 'occurs at' relation to capture the type of sequence or motif at which an MF occurs, e.g. 'occurs at' n_terminal_region (SO:0100014)