Annotation Conf. Call December 10, 2013

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Revision as of 17:29, 3 December 2013 by Pascale (talk | contribs) (→‎Agenda)
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Agenda

ubiquitin hydrolase

Pascale

  • Confusion between use of:

GO:0004221 ubiquitin thiolesterase activity

and

GO:0004843 ubiquitin-specific protease activity


1) ubiquitin thiolesterase activity: Catalysis of the reaction: ubiquitin C-terminal thioester + H2O = ubiquitin + a thiol (mapped to EC:3.1.2.15)

2) ubiquitin-specific protease activity: Catalysis of the hydrolysis of various forms of polymeric ubiquitin sequences (not mapped to any EC term).

However my understanding is that, although the reaction is sulfur-dependent, it's still a protease, and NOT a thiolesterase. Is this right ?

Those annotations are also in the following InterPro families:

IPR001394 IPR001578 IPR006615 IPR018200

I have the feeling the ubiquitin thiolesterase activity is not a real reaction. See http://sourceforge.net/p/geneontology/ontology-requests/10519/ for request to obsolete. I am waiting for the Swiss-Prot enzyme expert for input (Kristian Axelsen)


Histone kinase terms (mentioning specific residues in term names)