Annotation Conf. Call July 23, 2013

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Agenda

Consolidating protein binding curation pipelines

  • Background- Some groups capture every protein binding experiment as a GO annotation, while some don't. Is protein binding really a molecular function? There is inconsistency across the consortium in how people annotate to protein binding and we have struggled to come up with guidelines for consistent curation for this term. Some groups don't annotate protein binding using GO because BioGRID or IntAct captures these interactions for their species/db. We want to keep protein binding terms in the ontology.
  • Proposal- Consolidate all protein binding curation pipelines into the GAF
    • Do we just take all annotations from all pipelines? Does this mean each GAF file will have a huge # of protein binding data/
    • Some groups have stricter guidelines for capturing protein binding annotations for GO (e.g. Pombase). Will this effort dilute those annotations?
    • Why not include all include all interaction data? It will be yet another process to figure out what the filtering step should be.
    • Should we use a mapping strategy to map these interactions to specific GO terms?