Annotation Conf. Call November 26, 2013
Agenda
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Column-16 curation questions
- Forward annotation example: In yeast, CNB1 is the regulatory subunit and CNA1 and CMP2 are the catalytic subunits of the Calcineurin complex (http://www.yeastgenome.org/cgi-bin/GO/goTerm.pl?goid=5955, phosphatase complex).
| DB (Col 2) | GO ID (Col 5) | ev.code | Reference (Col 6) | Extension (Col 16) |
|---|---|---|---|---|
| CNB1 | GO:8597 (calcium-dependent protein S/T phosphatase regulator activity) | IDA | PMID:1321337 | has_regulation_target: CNA1, CMP2 |
| CNA1 | GO:4723 (calcium-dependent protein S/T phosphatase) | IDA | PMID:1321337 | requires_regulator: CNB1 |
| CMP2 | GO:4723 (calcium-dependent protein S/T phosphatase) | IDA | PMID:1321337 | requires_regulator: CNB1 |
- RAD51 has increased strand exchange activity in the presence of RPA complex. How do we capture this in col-16?
| DB (Col 2) | GO ID (Col 5) | ev.code | Reference (Col 6) | Extension (Col 16) |
|---|---|---|---|---|
| RAD51 | GO:recombinase activity | IDA | PMID:8066464 | ? (Replication protein A complex serves as an accessory factor or regulator, but RPA is a complex) |
- Would you add the substrate information in col-16 for phosphorylation BP annotation if we have already captured the substrate for the Kinase activity, MF annotation?