Has small molecular activator: Difference between revisions

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CHEBI:24431 ! chemical entity  
CHEBI:24431 ! chemical entity  


==Annotation Extension Usage Examples==
==== Annotation Extension Usage Examples ====


=== Specifying that a gene product is activated by a specific chemical ====
1. zinc activated ligand-gated ion channel (ZACN) is activated by Zn2+, PMID:12381728
So the annotation would be;
{| class="wikitable" border="1"
!DB (Col 2)
!Object (Col 3)
!GO ID (Col 5)
!Reference (Col 6)
!Extension (Col 16)
|-
|Q401N2
|ZACN
|GO:0048471
|PMID:12381728
|activated_by (ChEBI:29105, zinc ions)
|-
|}
==== Using examples to demonstrate [[Folding_and_Unfolding]] using the relationship activated_by ====
1. zinc activated ligand-gated ion channel (ZACN) is activated by Zn2+, PMID:12381728
So the annotation would be;
{| class="wikitable" border="1"
! Folded/unfolded
!DB (Col 2)
!Object (Col 3)
!GO ID (Col 5)
!Reference (Col 6)
!Extension (Col 16)
|-
| Unfolded
|Q401N2
|ZACN
|GO:0048471 <span style="color:green">ligand-gated ion channel activity</span>
|PMID:12381728
|activated_by (ChEBI:29105, <span style="color:green">zinc ions</span>)
|-
| Folded
|Q401N2
|New GO term <span style="color:green">zinc activated ligand-gated ion channel activity</span>
|PMID:12381728
|Parent for new GO term: is_a GO:0048471 <span style="color:green">ligand-gated ion channel activity</span>
|-
|}


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Revision as of 10:37, 9 May 2014

Definition

Identifies a chemical substance that increases the activity of the gene product.

Comment

This relation should not be used to annotate one gene product regulating another's activity; a regulator Molecular Function or regulation Biological Process should be used in such cases.

Synonyms

activated_by_chemical (EXACT)

activated_by_substance (EXACT)

activity_increased_by (EXACT)

Child terms

  • None.

Scope of use

Domain

GO:0003674 ! molecular_function

Range

CHEBI:24431 ! chemical entity

Annotation Extension Usage Examples

Specifying that a gene product is activated by a specific chemical =

1. zinc activated ligand-gated ion channel (ZACN) is activated by Zn2+, PMID:12381728

So the annotation would be;

DB (Col 2) Object (Col 3) GO ID (Col 5) Reference (Col 6) Extension (Col 16)
Q401N2 ZACN GO:0048471 PMID:12381728 activated_by (ChEBI:29105, zinc ions)

Using examples to demonstrate Folding_and_Unfolding using the relationship activated_by

1. zinc activated ligand-gated ion channel (ZACN) is activated by Zn2+, PMID:12381728

So the annotation would be;

Folded/unfolded DB (Col 2) Object (Col 3) GO ID (Col 5) Reference (Col 6) Extension (Col 16)
Unfolded Q401N2 ZACN GO:0048471 ligand-gated ion channel activity PMID:12381728 activated_by (ChEBI:29105, zinc ions)
Folded Q401N2 New GO term zinc activated ligand-gated ion channel activity PMID:12381728 Parent for new GO term: is_a GO:0048471 ligand-gated ion channel activity

Back to Annotation usage examples for each annotation extension relation