Has small molecular activator

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Definition

Identifies a chemical substance that increases the activity of the gene product.

Comment

This relation should not be used to annotate one gene product regulating another's activity; a regulator Molecular Function or regulation Biological Process should be used in such cases.

Synonyms

activated_by_chemical (EXACT)

activated_by_substance (EXACT)

activity_increased_by (EXACT)

Child terms

• None.

Scope of use

Domain

GO:0003674 ! molecular_function

Range

CHEBI:24431 ! chemical entity

Annotation Extension Usage Examples

Specifying that a gene product is activated by a specific chemical

1. zinc activated ligand-gated ion channel (ZACN) is activated by Zn2+, PMID:12381728

So the annotation would be:

DB (Col 2)	Object (Col 3)	GO ID (Col 5)	Reference (Col 6)	Extension (Col 16)
Q401N2	ZACN	GO:0048471	PMID:12381728	activated_by (ChEBI:29105, zinc ions)

Using examples to demonstrate Folding_and_Unfolding using the relationship activated_by

1. zinc activated ligand-gated ion channel (ZACN) is activated by Zn2+, PMID:12381728

Folded/unfolded	DB (Col 2)	Object (Col 3)	GO ID (Col 5)	Reference (Col 6)	Extension (Col 16)	Parent terms for new folded GO term
Unfolded	Q401N2	ZACN	GO:0048471 ligand-gated ion channel activity	PMID:12381728	activated_by (ChEBI:29105, zinc ions)
Folded	Q401N2	ZACN	New GO term zinc-gated ion channel activity	PMID:12381728		is_a GO:0048471 ligand-gated ion channel activity

OWL class expression: GO:0006509 ligand-gated ion channel activity AND activated_by SOME ChEBI:29105 zinc ions

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