Annotation Extension Relation:during

THIS RELATION IS DEPRECATED

 

==Definition==

Identifies a process during which a molecular function or biological process occurs or a cellular component is present.

==Child terms==

* [[Annotation_Extension_Relation:exists_during|exists_during]]
* [[Annotation_Extension_Relation:happens_during|happens_during]]

==Scope of use==

===Domain===

BFO:0000001 ! entity (Biological Process, Molecular Function or Cellular Component)

===Range===

BFO:0000007 ! process (Biological Process or Molecular Function) 

==Annotation Extension Usage Examples==

'''1. Protein localized to a cellular component during a specified process'''

Statement from paper:

''When cells were exposed to 1 M KCl, GFP-Ssp1 protein became largely associated with the plasma membrane, primarily at the polar zones (Figure ​(Figure3A,3A, right panel). In addition, many cells exhibited multiple foci of increased fluorescence under the cell surface near the poles.''



{| class="wikitable" border="1"
|-
! Gene Name (col 2)
! GO ID (col 5)
! Reference (col 6)
! Evidence (col 7)
! Annotation Extension (col 16)
|-
| SPCC297.03  <span style="color:green">ssp1</span>
| GO:0051285 <span style="color:green">cell cortex of cell tip</span>
| PMID:10233158
| IDA
| during(GO:0033554 <span style="color:green">cellular response to stress</span>)

|}


'''2. Regulation of cell proliferation during organ development'''

Statement from paper:

''...we used a low cell density culture system to demonstrate that fetal pancreas progenitor cells differentiate into insulin-positive β cells in the presence of laminin-1...In the presence of laminin-1, BMPs-4, -5 and -6 promoted the formation of cystic colonies (shown for BMP-6; Fig. 2)...To determine whether the colonies contained proliferating cells, BrdU labelling was performed during the last 16 hours of culture. Up to 10 BrdU-positive cells per colony were detected ( Fig. 5), providing evidence that cellular proliferation contributed to colony formation...Histology revealed the colonies to be duct-like structures containing various forms of epithelial cells surrounding a central lumen (Fig. 6).''



{| class="wikitable" border="1"
|-
! Gene Name (col 2)
! GO ID (col 5)
! Reference (col 6)
! Evidence (col 7)
! Annotation Extension (col 16)
|-
| P22003  <span style="color:green">BMP5</span>
| GO:0050679 <span style="color:green">positive regulation of epithelial cell proliferation</span>
| PMID:11865031
| IDA
| during(GO:0031016 <span style="color:green">pancreas development</span>)

|}


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