Happens during
Definition
Identifies a process during which a biological process occurs
Comment
To link a physical entity to a process by duration, use exists_during. Only use this term is the role of the gene product in the process is unclear, but occurs during a specific term. Consider the use of the relationship part_of is the process is definitely part of the biological process
Synonym
occurs_during (EXACT)
Child terms
- None.
Scope of use
Domain
BFO:0000007 ! process (Biological Process or Molecular Function)
Range
GO:0008150 ! Biological Process
Annotation Extension Usage Examples
1. A process occurring during cell development
Statement from paper:
In most cell systems that have been examined, the primary signal transduction pathway for BMPs involves phosphorylation of Smad-1 [22]... To determine if BMP-5 initiates similar signaling events in sympathetic neurons, cultured sympathetic neurons grown in the absence of glial cells were treated with BMP-5 for 30 or 60 min then analyzed by Western blotting using Abs specific for total Smad-1 or for phosphorylated Smad-1. Phosphorylation of Smad-1 is evident within 30 min after exposure to BMP-5 (Figure 4A) with significantly increased pSmad-1 levels apparent at 60min. In contrast, treatment with BMP-5 did not alter levels of total Smad-1 (Figure 4B).
Gene Name (col 2) | GO ID (col 5) | Reference (col 6) | Evidence (col 7) | Annotation Extension (col 16) |
---|---|---|---|---|
P22003 BMP5 | GO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation | PMID:11580864 | IDA | happens_during(GO:0016358 dendrite development) |
2. A process occurring during a cell cycle phase
Statement from paper:
We here show that the mitotic master phosphatase Cdc14 targets Yen1 to the nucleus in early anaphase through the FEAR network. In Figure 2, Yen1 re-localizes back to the nucleus in early anaphase in a Cdc14-dependent manner.
Gene Name (col 2) | GO ID (col 5) | Reference (col 6) | Evidence (col 7) | Annotation Extension (col 16) |
---|---|---|---|---|
Q00684 cdc14 | GO:0034504 protein localization to nucleus | PMID:24626187 | happens_during(GO:0000090 mitotic anaphase) |
Using examples to demonstrate Folding_and_Unfolding using the relationship happens_during
2. Cdc14 targets Yen1 to the nucleus in early anaphase, PMID:24626187
Folded/unfolded | DB (Col 2) | Object (Col 3) | GO ID (Col 5) | Reference (Col 6) | Extension (Col 16) | Parent terms for new folded GO term |
---|---|---|---|---|---|---|
Unfolded | Q00684 | cdc14 | GO:0034504 protein localization to nucleus | PMID:24626187 | happens_during(GO:0000090 mitotic anaphase) | |
Folded | Q00684 | cdc14 | New potential GO term protein localisation to nucleus during mitotic anaphase | PMID:24626187 | happens_during GO:0048471 mitotic anaphase |
Back to Annotation usage examples for each annotation extension relation