Annotation Extension Relation:has regulation target

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Definition

Identifies a gene or gene product affected by a regulation Biological Process or regulator Molecular Function.

Child terms

• None

Scope of use

Domain

GO:0065007 ! biological regulation

Range

ENTITY_UNION:0000005 ! chemical, gene product or complex

Annotation Extension Usage Examples

Loss of transcription factor activity affects gene expression:

Statements from paper:

Indeed, LGG-1 was massively upregulated in atf-2(tm467) mutant embryos, as compared with the wild type (Fig. 6A). We observed a similar extent of BEC-1 upregulation in the atf-2-deficient background (data not shown).

Gene Name (col 2)	GO ID (col 5)	Reference (col 6)	Evidence (col 7)	Annotation Extension (col 16)
WBGene00000220 atf-2(tm467)	GO:0000122 negative regulation of transcription from RNA polymerase II promoter	PMID:21502138	IMP	has_regulation_target(WB:WBGene00000247 bec-1)|has_regulation_target(WB:WBGene00002980 lgg-1 Specifying the gene which is a target of a transcription factor gene transcription targets This example is still under discussion. Statement example: DNA binding transcription factor A binds the promoter of Polo2 and increases transcription of Polo2 Folded/unfolded Gene Name (col 2) GO ID (col 5) Reference (col 6) Evidence (col 7) Annotation Extension (col 16) Parent terms of new folded GO term Unfolded Pxxx transcription factor A GO:0001228 RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription PMID:xxx IDA has_regulation_target(UNIPROT:Qxxx Polo2) Back to Annotation Extension: Capturing participants Back to Annotation usage examples for each annotation extension relation