Annotation Extension Relation:has regulation target

Redirect to:

• Annotation

USAGE OF THIS RELATION HAS BEEN DEPRECATED

 


==Definition==

Identifies a gene or gene product affected by a regulation Biological Process or regulator Molecular Function.


==Child terms==

* None

==Scope of use==

===Domain===

GO:0065007 ! biological regulation

===Range===

[[ENTITY_UNION:0000005]] ! chemical, gene product or complex

==Annotation Extension Usage Examples==

'''Loss of transcription factor activity affects gene expression:'''

Statements from paper:  

''Indeed, LGG-1 was massively upregulated in atf-2(tm467) mutant embryos, as compared with the wild type (Fig. 6A). We observed a similar extent of BEC-1 upregulation in the atf-2-deficient background (data not shown).''  

Expressed in LEGO: http://go-genkisugi.rhcloud.com/seed/model/gomodel:taxon_6239-548253760000031


{| class="wikitable" border="1"
|-
! Gene Name (col 2)
! GO ID (col 5)
! Reference (col 6)
! Evidence (col 7)
! Annotation Extension (col 16)
|-
| WBGene00000220 atf-2(tm467)
|GO:0000122 <span style="color:green">negative regulation of transcription from RNA polymerase II promoter</span>
| PMID:21502138
| IMP
| has_regulation_target(WB:WBGene00000247 <span style="color:green">bec-1</span>) 'pipe' has_regulation_target(WB:WBGene00002980 <span style="color:green">lgg-1</span>

|}

== Using examples (from above) to demonstrate Folding_and_Unfolding using the relationship has_regulation_target ==
==== Specifying the gene which is a target of a transcription factor ====

'''gene transcription targets'''  

Statement example: 

''Indeed, LGG-1 was massively upregulated in atf-2(tm467) mutant embryos, as compared with the wild type (Fig. 6A). We observed a similar extent of BEC-1 upregulation in the atf-2-deficient background (data not shown).''

{| class="wikitable" border="1"
|-
! Folded/unfolded
! Gene Name (col 2)
! GO ID (col 5)
! Reference (col 6)
! Evidence (col 7)
! Annotation Extension (col 16)
! Parent terms of new folded GO term
|-
| Unfolded
| WBGene00000220 <span style="color:green">atf-2(tm467)</span>
| GO:0000122 <span style="color:green">negative regulation of transcription from RNA polymerase II promoter</span>
| PMID:21502138 
| IMP
| has_regulation_target(WB:WBGene00000247 <span style="color:green">bec-1</span>)'pipe' has_regulation_target(WB:WBGene00002980 <span style="color:green">lgg-1</span>
|-
| Folded
| WBGene00000220 <span style="color:green">atf-2(tm467)</span>
| GO:0000122 <span style="color:green">negative regulation of transcription from RNA polymerase II promoter</span>
| PMID:21502138 
| IMP
| 
| <span style="color:red">No new GO term created</span>
|-
|}
'''OWL class expression:''' GO:0000122 <span style="color:red">negative regulation of transcription from RNA polymerase II promoter</span> AND has_regulation_target SOME WB:WBGene00000247 <span style="color:red">bec-1</span>
'''OWL class expression:''' GO:0000122 <span style="color:red">negative regulation of transcription from RNA polymerase II promoter</span> AND has_regulation_target SOME WB:WBGene00002980 <span style="color:red">lgg-1</span>