Has small molecular inhibitor: Difference between revisions
m (moved Inhibited by to Annotation Extension Relation:inhibited by: To distinguish the annotation extension relations from other relations) |
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Back to [http://wiki.geneontology.org/index.php/Annotation_usage_examples_for_each_annotation_extension_relation Annotation usage examples for each annotation extension relation] | |||
==Definition== | ==Definition== | ||
Identifies a chemical substance that decreases the activity of the gene product. | Identifies a chemical substance that decreases the activity of the gene product. | ||
==Comment== | |||
This relation should not be used to annotate one gene product regulating another's activity; a regulator Molecular Function or regulation Biological Process should be used in such cases. | |||
==Synonyms== | |||
activity_decreased_by (EXACT) | |||
inhibited_by_chemical (EXACT) | |||
inhibited_by_substance (EXACT) | |||
==Child terms== | ==Child terms== | ||
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==Annotation Extension Usage Examples== | ==Annotation Extension Usage Examples== | ||
{| class="wikitable" border="1" | |||
|- | |||
! Gene Name (col 2) | |||
! GO ID (col 5) | |||
! Reference (col 6) | |||
! Evidence (col 7) | |||
! With (col 8) | |||
! Annotation Extension (col 16) | |||
|- | |||
|P10869, <font color = "green">HOM3</font> | |||
| GO:0004072 <font color = "green">aspartate kinase activity</font> | |||
| PMID:18626862 | |||
| IDA | |||
| | |||
|inhibited_by: CHEBI:16857<font color = "green">L-threonine </font> | |||
|- | |||
|P32783, <font color = "green">ABD1</font> | |||
|GO:0004482, <font color = "green">mRNA (guanine-N7-)-methyltransferase activity</font> | |||
|PMID: 7623811 | |||
|IDA | |||
| | |||
|inhibited_by: CHEBI:16680 <font color = "green">S-adenosyl-L-homocysteine</font> | |||
|- | |||
|} | |||
== Using examples to demonstrate [[Folding_and_Unfolding]] using the relationship inhibited_by == | |||
{| class="wikitable" border="1" | |||
! Folded/unfolded | |||
!Object (Col 2) | |||
!GO ID (Col 5) | |||
!Reference (Col 6) | |||
!Evidence | |||
!Extension (Col 16) | |||
!Parent terms for new folded GO term | |||
|- | |||
| Unfolded | |||
| P10869, <font color = "green">HOM3</font> | |||
| GO:0004072 <font color = "green">aspartate kinase activity</font> | |||
| PMID:18626862 | |||
| IDA | |||
| inhibited_by: CHEBI:16857<font color = "green">L-threonine </font> | |||
| | |||
|- | |||
| Folded | |||
| P10869, <font color = "green">HOM3</font> | |||
| GO:0004072 <font color = "green">aspartate kinase activity</font> | |||
| PMID:18626862 | |||
| IDA | |||
| | |||
| <span style="color:red">No new GO term created</span> | |||
|- | |||
|} | |||
'''OWL class expression:''' GO: 0004072 <font color = "red">aspartate kinase activity</font> is inhibited_by SOME CHEBI: 16857 <font color = "red">L-threonine </font> | |||
{| class="wikitable" border="1" | |||
! Folded/unfolded | |||
!Object (Col 2) | |||
!GO ID (Col 5) | |||
!Reference (Col 6) | |||
!Evidence | |||
!Extension (Col 16) | |||
!Parent terms for new folded GO term | |||
|- | |||
| Unfolded | |||
| P32783, <font color = "green">ABD1</font> | |||
| GO:0004482, <font color = "green">mRNA (guanine-N7-)-methyltransferase activity</font> | |||
| PMID: 7623811 | |||
| IDA | |||
| inhibited_by: CHEBI:16680 <font color = "green">S-adenosyl-L-homocysteine</font> | |||
| | |||
|- | |||
| folded | |||
| P32783, <font color = "green">ABD1</font> | |||
| GO:0004482, <font color = "green">mRNA (guanine-N7-)-methyltransferase activity</font> | |||
| PMID: 7623811 | |||
| IDA | |||
| | |||
| <span style="color:red">No new GO term created</span> | |||
|- | |||
|} | |||
'''OWL class expression:''' GO: 0004482, <font color = "red">mRNA (guanine-N7-)-methyltransferase activity</font> is inhibited_by SOME CHEBI:16680 <font color = "red">S-adenosyl-L-homocysteine</font> | |||
---- | |||
Back to [http://wiki.geneontology.org/index.php/Annotation_usage_examples_for_each_annotation_extension_relation Annotation usage examples for each annotation extension relation] | |||
[[Category:relations]] | |||
[[Category:annotation extension]] |
Revision as of 07:07, 5 March 2015
Back to Annotation usage examples for each annotation extension relation
Definition
Identifies a chemical substance that decreases the activity of the gene product.
Comment
This relation should not be used to annotate one gene product regulating another's activity; a regulator Molecular Function or regulation Biological Process should be used in such cases.
Synonyms
activity_decreased_by (EXACT)
inhibited_by_chemical (EXACT)
inhibited_by_substance (EXACT)
Child terms
- None.
Scope of use
Domain
GO:0003674 ! molecular_function
Range
CHEBI:24431 ! chemical entity
Annotation Extension Usage Examples
Gene Name (col 2) | GO ID (col 5) | Reference (col 6) | Evidence (col 7) | With (col 8) | Annotation Extension (col 16) |
---|---|---|---|---|---|
P10869, HOM3 | GO:0004072 aspartate kinase activity | PMID:18626862 | IDA | inhibited_by: CHEBI:16857L-threonine | |
P32783, ABD1 | GO:0004482, mRNA (guanine-N7-)-methyltransferase activity | PMID: 7623811 | IDA | inhibited_by: CHEBI:16680 S-adenosyl-L-homocysteine |
Using examples to demonstrate Folding_and_Unfolding using the relationship inhibited_by
Folded/unfolded | Object (Col 2) | GO ID (Col 5) | Reference (Col 6) | Evidence | Extension (Col 16) | Parent terms for new folded GO term |
---|---|---|---|---|---|---|
Unfolded | P10869, HOM3 | GO:0004072 aspartate kinase activity | PMID:18626862 | IDA | inhibited_by: CHEBI:16857L-threonine | |
Folded | P10869, HOM3 | GO:0004072 aspartate kinase activity | PMID:18626862 | IDA | No new GO term created |
OWL class expression: GO: 0004072 aspartate kinase activity is inhibited_by SOME CHEBI: 16857 L-threonine
Folded/unfolded | Object (Col 2) | GO ID (Col 5) | Reference (Col 6) | Evidence | Extension (Col 16) | Parent terms for new folded GO term |
---|---|---|---|---|---|---|
Unfolded | P32783, ABD1 | GO:0004482, mRNA (guanine-N7-)-methyltransferase activity | PMID: 7623811 | IDA | inhibited_by: CHEBI:16680 S-adenosyl-L-homocysteine | |
folded | P32783, ABD1 | GO:0004482, mRNA (guanine-N7-)-methyltransferase activity | PMID: 7623811 | IDA | No new GO term created |
OWL class expression: GO: 0004482, mRNA (guanine-N7-)-methyltransferase activity is inhibited_by SOME CHEBI:16680 S-adenosyl-L-homocysteine
Back to Annotation usage examples for each annotation extension relation