Has small molecular inhibitor: Difference between revisions

From GO Wiki
Jump to navigation Jump to search
m (moved Inhibited by to Annotation Extension Relation:inhibited by: To distinguish the annotation extension relations from other relations)
(17 intermediate revisions by 3 users not shown)
Line 1: Line 1:
Back to [http://wiki.geneontology.org/index.php/Annotation_usage_examples_for_each_annotation_extension_relation  Annotation usage examples for each annotation extension relation]
==Definition==
==Definition==


Identifies a chemical substance that decreases the activity of the gene product.
Identifies a chemical substance that decreases the activity of the gene product.
==Comment==
This relation should not be used to annotate one gene product regulating another's activity; a regulator Molecular Function or regulation Biological Process should be used in such cases.
==Synonyms==
activity_decreased_by (EXACT)
inhibited_by_chemical (EXACT)
inhibited_by_substance (EXACT)


==Child terms==
==Child terms==
Line 18: Line 32:


==Annotation Extension Usage Examples==
==Annotation Extension Usage Examples==
{| class="wikitable" border="1"
|-
! Gene Name (col 2)
! GO ID (col 5)
! Reference (col 6)
! Evidence (col 7)
! With (col 8)
! Annotation Extension (col 16)
|-
|P10869, <font color = "green">HOM3</font>
| GO:0004072 <font color = "green">aspartate kinase activity</font>
| PMID:18626862
| IDA
|
|inhibited_by: CHEBI:16857<font color = "green">L-threonine </font>
|-
|P32783, <font color = "green">ABD1</font>
|GO:0004482, <font color = "green">mRNA (guanine-N7-)-methyltransferase activity</font>
|PMID: 7623811
|IDA
|
|inhibited_by: CHEBI:16680 <font color = "green">S-adenosyl-L-homocysteine</font>
|-
|}
== Using examples to demonstrate [[Folding_and_Unfolding]] using the relationship inhibited_by ==
{| class="wikitable" border="1"
! Folded/unfolded
!Object (Col 2)
!GO ID (Col 5)
!Reference (Col 6)
!Evidence
!Extension (Col 16)
!Parent terms for new folded GO term
|-
| Unfolded
| P10869, <font color = "green">HOM3</font>
| GO:0004072 <font color = "green">aspartate kinase activity</font>
| PMID:18626862
| IDA
| inhibited_by: CHEBI:16857<font color = "green">L-threonine </font>
|
|-
| Folded
| P10869, <font color = "green">HOM3</font>
| GO:0004072 <font color = "green">aspartate kinase activity</font>
| PMID:18626862
| IDA
|
| <span style="color:red">No new GO term created</span>
|-
|}
'''OWL class expression:''' GO: 0004072 <font color = "red">aspartate kinase activity</font> is inhibited_by SOME CHEBI: 16857 <font color = "red">L-threonine </font>
{| class="wikitable" border="1"
! Folded/unfolded
!Object (Col 2)
!GO ID (Col 5)
!Reference (Col 6)
!Evidence
!Extension (Col 16)
!Parent terms for new folded GO term
|-
| Unfolded
| P32783, <font color = "green">ABD1</font>
| GO:0004482, <font color = "green">mRNA (guanine-N7-)-methyltransferase activity</font>
| PMID: 7623811
| IDA
| inhibited_by: CHEBI:16680 <font color = "green">S-adenosyl-L-homocysteine</font>
|
|-
| folded
| P32783, <font color = "green">ABD1</font>
| GO:0004482, <font color = "green">mRNA (guanine-N7-)-methyltransferase activity</font>
| PMID: 7623811
| IDA
|
| <span style="color:red">No new GO term created</span>
|-
|}
'''OWL class expression:''' GO: 0004482, <font color = "red">mRNA (guanine-N7-)-methyltransferase activity</font> is inhibited_by SOME CHEBI:16680 <font color = "red">S-adenosyl-L-homocysteine</font>
----
Back to [http://wiki.geneontology.org/index.php/Annotation_usage_examples_for_each_annotation_extension_relation  Annotation usage examples for each annotation extension relation]
[[Category:relations]]
[[Category:annotation extension]]

Revision as of 07:07, 5 March 2015

Back to Annotation usage examples for each annotation extension relation

Definition

Identifies a chemical substance that decreases the activity of the gene product.

Comment

This relation should not be used to annotate one gene product regulating another's activity; a regulator Molecular Function or regulation Biological Process should be used in such cases.

Synonyms

activity_decreased_by (EXACT)

inhibited_by_chemical (EXACT)

inhibited_by_substance (EXACT)

Child terms

  • None.

Scope of use

Domain

GO:0003674 ! molecular_function

Range

CHEBI:24431 ! chemical entity

Annotation Extension Usage Examples

Gene Name (col 2) GO ID (col 5) Reference (col 6) Evidence (col 7) With (col 8) Annotation Extension (col 16)
P10869, HOM3 GO:0004072 aspartate kinase activity PMID:18626862 IDA inhibited_by: CHEBI:16857L-threonine
P32783, ABD1 GO:0004482, mRNA (guanine-N7-)-methyltransferase activity PMID: 7623811 IDA inhibited_by: CHEBI:16680 S-adenosyl-L-homocysteine

Using examples to demonstrate Folding_and_Unfolding using the relationship inhibited_by

Folded/unfolded Object (Col 2) GO ID (Col 5) Reference (Col 6) Evidence Extension (Col 16) Parent terms for new folded GO term
Unfolded P10869, HOM3 GO:0004072 aspartate kinase activity PMID:18626862 IDA inhibited_by: CHEBI:16857L-threonine
Folded P10869, HOM3 GO:0004072 aspartate kinase activity PMID:18626862 IDA No new GO term created

OWL class expression: GO: 0004072 aspartate kinase activity is inhibited_by SOME CHEBI: 16857 L-threonine


Folded/unfolded Object (Col 2) GO ID (Col 5) Reference (Col 6) Evidence Extension (Col 16) Parent terms for new folded GO term
Unfolded P32783, ABD1 GO:0004482, mRNA (guanine-N7-)-methyltransferase activity PMID: 7623811 IDA inhibited_by: CHEBI:16680 S-adenosyl-L-homocysteine
folded P32783, ABD1 GO:0004482, mRNA (guanine-N7-)-methyltransferase activity PMID: 7623811 IDA No new GO term created

OWL class expression: GO: 0004482, mRNA (guanine-N7-)-methyltransferase activity is inhibited_by SOME CHEBI:16680 S-adenosyl-L-homocysteine


Back to Annotation usage examples for each annotation extension relation