Has small molecular inhibitor: Difference between revisions

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! Annotation Extension (col 16)
! Annotation Extension (col 16)
|-
|-
|
|P10869, <font color = "green">HOM3</font>
| GO:0004072 <font color = "green">aspartate kinase activity</font>
| PMID:18626862
| IDA
|  
|  
|inhibited_by: CHEBI:16857<font color = "green">L-threonine </font>
|-
|P32783, <font color = "green">ABD1</font>
|GO:0004482, <font color = "green">mRNA (guanine-N7-)-methyltransferase activity</font>
|PMID: 7623811
|IDA
|
|
|  
|inhibited_by: CHEBI:16680 <font color = "green">S-adenosyl-L-homocysteine</font>
|  
|-
|
 
|}
|}


Line 55: Line 62:
{| class="wikitable" border="1"
{| class="wikitable" border="1"
! Folded/unfolded
! Folded/unfolded
!DB (Col 2)
!Object (Col 2)
!Object (Col 3)
!GO ID (Col 5)
!GO ID (Col 5)
!Reference (Col 6)
!Reference (Col 6)
!Evidence
!Extension (Col 16)
!Extension (Col 16)
!Parent terms for new folded GO term
!Parent terms for new folded GO term
|-
|-
| Unfolded
| Unfolded
|
| P10869, <font color = "green">HOM3</font>
|
| GO:0004072 <font color = "green">aspartate kinase activity</font>
|  
| PMID:18626862
|  
| IDA
|  
| inhibited_by: CHEBI:16857<font color = "green">L-threonine </font>
|
|
|-
|-
| Folded
| Folded
|
| P10869, <font color = "green">HOM3</font>
|
| GO:0004072 <font color = "green">aspartate kinase activity</font>
|
| PMID:18626862
|
| IDA
|
|
|
| <span style="color:red">No new GO term created</span>
|-
|-
|}
|}


'''OWL class expression:''' GO: 0004072 <font color = "red">aspartate kinase activity</font> is inhibited_by SOME CHEBI: 16857 <font color = "red">L-threonine </font>




'''OWL class expression:'''
{| class="wikitable" border="1"
! Folded/unfolded
!Object (Col 2)
!GO ID (Col 5)
!Reference (Col 6)
!Evidence
!Extension (Col 16)
!Parent terms for new folded GO term
|-
| Unfolded
| P32783, <font color = "green">ABD1</font>
| GO:0004482, <font color = "green">mRNA (guanine-N7-)-methyltransferase activity</font>
| PMID: 7623811
| IDA
| inhibited_by: CHEBI:16680 <font color = "green">S-adenosyl-L-homocysteine</font>
|
|-
| folded
| P32783, <font color = "green">ABD1</font>
| GO:0004482, <font color = "green">mRNA (guanine-N7-)-methyltransferase activity</font>
| PMID: 7623811
| IDA
|
| <span style="color:red">No new GO term created</span>
|-
|}


'''OWL class expression:''' GO: 0004482, <font color = "red">mRNA (guanine-N7-)-methyltransferase activity</font> is inhibited_by SOME CHEBI:16680 <font color = "red">S-adenosyl-L-homocysteine</font>


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Revision as of 07:07, 5 March 2015

Back to Annotation usage examples for each annotation extension relation

Definition

Identifies a chemical substance that decreases the activity of the gene product.

Comment

This relation should not be used to annotate one gene product regulating another's activity; a regulator Molecular Function or regulation Biological Process should be used in such cases.

Synonyms

activity_decreased_by (EXACT)

inhibited_by_chemical (EXACT)

inhibited_by_substance (EXACT)

Child terms

  • None.

Scope of use

Domain

GO:0003674 ! molecular_function

Range

CHEBI:24431 ! chemical entity

Annotation Extension Usage Examples

Gene Name (col 2) GO ID (col 5) Reference (col 6) Evidence (col 7) With (col 8) Annotation Extension (col 16)
P10869, HOM3 GO:0004072 aspartate kinase activity PMID:18626862 IDA inhibited_by: CHEBI:16857L-threonine
P32783, ABD1 GO:0004482, mRNA (guanine-N7-)-methyltransferase activity PMID: 7623811 IDA inhibited_by: CHEBI:16680 S-adenosyl-L-homocysteine

Using examples to demonstrate Folding_and_Unfolding using the relationship inhibited_by

Folded/unfolded Object (Col 2) GO ID (Col 5) Reference (Col 6) Evidence Extension (Col 16) Parent terms for new folded GO term
Unfolded P10869, HOM3 GO:0004072 aspartate kinase activity PMID:18626862 IDA inhibited_by: CHEBI:16857L-threonine
Folded P10869, HOM3 GO:0004072 aspartate kinase activity PMID:18626862 IDA No new GO term created

OWL class expression: GO: 0004072 aspartate kinase activity is inhibited_by SOME CHEBI: 16857 L-threonine


Folded/unfolded Object (Col 2) GO ID (Col 5) Reference (Col 6) Evidence Extension (Col 16) Parent terms for new folded GO term
Unfolded P32783, ABD1 GO:0004482, mRNA (guanine-N7-)-methyltransferase activity PMID: 7623811 IDA inhibited_by: CHEBI:16680 S-adenosyl-L-homocysteine
folded P32783, ABD1 GO:0004482, mRNA (guanine-N7-)-methyltransferase activity PMID: 7623811 IDA No new GO term created

OWL class expression: GO: 0004482, mRNA (guanine-N7-)-methyltransferase activity is inhibited_by SOME CHEBI:16680 S-adenosyl-L-homocysteine

Back to Annotation usage examples for each annotation extension relation

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