Annotation Extension Relation:requires regulator
Definition
The annotated gene product requires regulation by the gene product or complex for its participation in the Molecular Function or Biological Process.
Child terms
- None.
Scope of use
Domain
BFO:0000007 ! process (Biological Process or Molecular Function)
Range
ENTITY_UNION:0000001 ! gene product or complex
Annotation Extension Usage Examples
Direct Activation of Bax by p53 Mediates Mitochondrial Membrane Permeabilization and Apoptosis
Statement from paper:
...we examined the effect of p53 on isolated mitochondria with and without Bax. Neither recombinant monomeric Bax nor native p53UVIP induced cytochrome c release on its own; however, incubation of mitochondria with both proteins caused cytochrome c release (Fig. 2B).
| Gene Name (col 2) | GO ID (col 5) | Reference (col 6) | Evidence (col 7) | Annotation Extension (col 16) |
|---|---|---|---|---|
| Q07812 | GO:0090200 positive regulation of release of cytochrome c from mitochondria | PMID:14963330 | IDA |
requires_regulator(UniProtKB:P04637 p53) |
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