Annotation Extension Relation:results in morphogenesis of: Difference between revisions

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==Definition==
==Definition==


Identifies the cell, tissue, or anatomical entity which under goes morphogenesis.
The relationship that links an entity with the process that results in the formation and shaping of that entity over time from an immature to a mature state.
 
Identifies the cell, tissue, or anatomical entity which are under going the morphogenic process.


==Child terms==
==Child terms==
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=== Enhancing Molecular Function and Biological Process Annotations ===
=== Enhancing Molecular Function and Biological Process Annotations ===


==== Specifying the cell or tissue type in which a process happens ====
==== Specifying the cell or tissue type which are under going the morphogenic process ====


'''1. Differentiation of a particular cell type:'''
'''1. A protein's involvement in changing a particular cell's shape:'''
 
Statement from paper:
 
''REN promoted neuronal differentiation of neural committed progenitor cells of CNS (ST14A cells, Fig. 7 A) or PNS (N2a cells, Fig. 7 B) origin.''
 
 
{| class="wikitable" border="1"
|-
! Gene Name (col 2)
! GO ID (col 5)
! Reference (col 6)
! Evidence (col 7)
! Annotation Extension (col 16)
|-
| MGI:2448712  <span style="color:green">Ren</span>
| GO:0030154 <span style="color:green">cell differentiation</span>
| PMID:12186855
| IDA
| occurs_in(CL:0000540 <span style="color:green">neuron</span>)
 
|}
 
 
'''2. A protein's involvement in changing a particular cell's shape:'''


Statement from paper:
Statement from paper:
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| PMID:10072545
| PMID:10072545
| IDA
| IDA
| occurs_in(CL:0000771 <span style="color:green">eosinophil</span>) 'pipe' occurs_in(CL:0000576 <span style="color:green">monocyte</span>)
| results_in_morphogenesis_of(CL:0000771 <span style="color:green">eosinophil</span>) 'pipe' results_in_morphogenesis_of(CL:0000576 <span style="color:green">monocyte</span>)
|}
|}


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More examples of this usage of occurs_in can be found on the documentation page for [[Column_16:_Cell_Type]]
More examples of this usage of occurs_in can be found on the documentation page for [[Column_16:_Cell_Type]]


== Using examples (from above) to demonstrate [[Folding_and_Unfolding]] using the relationship results_in_morphogenesis_of ==


== Using examples (from above) to demonstrate [[Folding_and_Unfolding]] using the relationship occurs_in ==
'''1. A protein's involvement in changing a particular cell's shape:'''
 
'''1. Differentiation of a particular cell type:'''
{| class="wikitable" border="1"
|-
! Folded/unfolded
! Gene Name (col 2)
! GO ID (col 5)
! Reference (col 6)
! Evidence (col 7)
! Annotation Extension (col 16)
! Parent terms of new folded GO term
|-
| Unfolded
| MGI:2448712  <span style="color:green">Ren</span>
| GO:0030154 <span style="color:green">cell differentiation</span>
| PMID:12186855
| IDA
| occurs_in(CL:0000540 <span style="color:green">neuron</span>)
|
|-
| Folded
| MGI:2448712  <span style="color:green">Ren</span>
| New GO ID <span style="color:green"> neuron cell differentiation</span>
| PMID:12186855
| IDA
|
|is_a <span style="color:red"> cell differentiation</span>
|}
 
 
'''2. A protein's involvement in changing a particular cell's shape:'''


Note the use of the pipe to create a multiple annotation extensions.
Note the use of the pipe to create a multiple annotation extensions.
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| PMID:10072545
| PMID:10072545
| IDA
| IDA
| occurs_in(CL:0000771 <span style="color:green">eosinophil</span>) 'pipe' occurs_in(CL:0000576 <span style="color:green">monocyte</span>)
| results_in_morphogenesis_of(CL:0000771 <span style="color:green">eosinophil</span>) 'pipe' results_in_morphogenesis_of(CL:0000576 <span style="color:green">monocyte</span>)
|
|
|-
|-

Latest revision as of 05:34, 16 May 2014

Back to Annotation usage examples for each annotation extension relation

Definition

The relationship that links an entity with the process that results in the formation and shaping of that entity over time from an immature to a mature state.

Identifies the cell, tissue, or anatomical entity which are under going the morphogenic process.

Child terms

  • None.

Scope of use

Domain

BFO:0000007 ! process (Biological Process or Molecular Function)

Range

ENTITY_UNION:0000006 ! entity

Annotation Extension Usage Examples

Enhancing Molecular Function and Biological Process Annotations

Specifying the cell or tissue type which are under going the morphogenic process

1. A protein's involvement in changing a particular cell's shape:

Statement from paper:

Eotaxin, eotaxin-2, and MCP-4 were the most potent inducers of eosinophil shape change, followed by MCP-3, while MCP-1 and IL-8 were inactive. MCP-4 alone showed a bell-shaped eosinophil dose-response curve over the dose range tested. Eotaxin and eotaxin-2 were inactive on monocytes (Fig. 2⇓B), whereas MCP-1, -3, and -4 all induced monocyte shape change, with MCP-3 exhibiting the highest potency.

Gene Name (col 2) GO ID (col 5) Reference (col 6) Evidence (col 7) Annotation Extension (col 16)
Q99616 MCP4 GO:0008360 regulation of cell shape PMID:10072545 IDA results_in_morphogenesis_of(CL:0000771 eosinophil) 'pipe' results_in_morphogenesis_of(CL:0000576 monocyte)

Note the use of the pipe to create a multiple annotation extensions. The interpretation of this annotation is MCP4 is involved in the regulation of eosinophil cell shape and monocyte cell shape.

More examples of this usage of occurs_in can be found on the documentation page for Column_16:_Cell_Type

Using examples (from above) to demonstrate Folding_and_Unfolding using the relationship results_in_morphogenesis_of

1. A protein's involvement in changing a particular cell's shape:

Note the use of the pipe to create a multiple annotation extensions.

Folded/unfolded Gene Name (col 2) GO ID (col 5) Reference (col 6) Evidence (col 7) Annotation Extension (col 16) Parent terms of new folded GO term
Unfolded Q99616 MCP4 GO:0008360 regulation of cell shape PMID:10072545 IDA results_in_morphogenesis_of(CL:0000771 eosinophil) 'pipe' results_in_morphogenesis_of(CL:0000576 monocyte)
Folded Q99616 MCP4 New GO ID regulation of eosinophil cell shape PMID:10072545 IDA is_a regulation of cell shape
Folded Q99616 MCP4 New GO ID regulation of monocyte cell shape PMID:10072545 IDA is_a regulation of cell shape

Back to Annotation usage examples for each annotation extension relation