Annotation Extension Relation:results in morphogenesis of
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Definition
Identifies the cell, tissue, or anatomical entity which are under going the morphogenic process.
Child terms
- None.
Scope of use
Domain
BFO:0000007 ! process (Biological Process or Molecular Function)
Range
ENTITY_UNION:0000006 ! entity
Annotation Extension Usage Examples
Enhancing Molecular Function and Biological Process Annotations
Specifying the cell or tissue type which undertake morphogenesis
1. Differentiation of a particular cell type:
Statement from paper:
REN promoted neuronal differentiation of neural committed progenitor cells of CNS (ST14A cells, Fig. 7 A) or PNS (N2a cells, Fig. 7 B) origin.
| Gene Name (col 2) | GO ID (col 5) | Reference (col 6) | Evidence (col 7) | Annotation Extension (col 16) |
|---|---|---|---|---|
| MGI:2448712 Ren | GO:0030154 cell differentiation | PMID:12186855 | IDA | occurs_in(CL:0000540 neuron) |
2. A protein's involvement in changing a particular cell's shape:
Statement from paper:
Eotaxin, eotaxin-2, and MCP-4 were the most potent inducers of eosinophil shape change, followed by MCP-3, while MCP-1 and IL-8 were inactive. MCP-4 alone showed a bell-shaped eosinophil dose-response curve over the dose range tested. Eotaxin and eotaxin-2 were inactive on monocytes (Fig. 2⇓B), whereas MCP-1, -3, and -4 all induced monocyte shape change, with MCP-3 exhibiting the highest potency.
| Gene Name (col 2) | GO ID (col 5) | Reference (col 6) | Evidence (col 7) | Annotation Extension (col 16) |
|---|---|---|---|---|
| Q99616 MCP4 | GO:0008360 regulation of cell shape | PMID:10072545 | IDA | occurs_in(CL:0000771 eosinophil) 'pipe' occurs_in(CL:0000576 monocyte) |
Note the use of the pipe to create a multiple annotation extensions. The interpretation of this annotation is MCP4 is involved in the regulation of eosinophil cell shape and monocyte cell shape.
More examples of this usage of occurs_in can be found on the documentation page for Column_16:_Cell_Type
Using examples (from above) to demonstrate Folding_and_Unfolding using the relationship occurs_in
1. Differentiation of a particular cell type:
| Folded/unfolded | Gene Name (col 2) | GO ID (col 5) | Reference (col 6) | Evidence (col 7) | Annotation Extension (col 16) | Parent terms of new folded GO term |
|---|---|---|---|---|---|---|
| Unfolded | MGI:2448712 Ren | GO:0030154 cell differentiation | PMID:12186855 | IDA | occurs_in(CL:0000540 neuron) | |
| Folded | MGI:2448712 Ren | New GO ID neuron cell differentiation | PMID:12186855 | IDA | is_a cell differentiation |
2. A protein's involvement in changing a particular cell's shape:
Note the use of the pipe to create a multiple annotation extensions.
| Folded/unfolded | Gene Name (col 2) | GO ID (col 5) | Reference (col 6) | Evidence (col 7) | Annotation Extension (col 16) | Parent terms of new folded GO term |
|---|---|---|---|---|---|---|
| Unfolded | Q99616 MCP4 | GO:0008360 regulation of cell shape | PMID:10072545 | IDA | occurs_in(CL:0000771 eosinophil) 'pipe' occurs_in(CL:0000576 monocyte) | |
| Folded | Q99616 MCP4 | New GO ID regulation of eosinophil cell shape | PMID:10072545 | IDA | is_a regulation of cell shape | |
| Folded | Q99616 MCP4 | New GO ID regulation of monocyte cell shape | PMID:10072545 | IDA | is_a regulation of cell shape |
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