Cardiac conduction: fish vs. mammals

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Birds:

Many avian species develop an AV-ring which plays a role similar to that of the mammalian AV-node (Szabo et al. Anat Rec. 1986 May;215(1):1-9. PubMed PMID:3706789.) [[1]]

Steps in CCS develoment in zebrafish:

From Genetic and physiologic dissection of the vertebrate cardiac conduction system. PLoS Biol. 2008 May 13;6(5):e109. PubMed PMID: 18479184; PubMed Central PMCID: PMC2430899. [[2]]

  1. Initially, a linear conduction travels across the heart tube from the sinus venosus to the OFT (20–24 hours postfertilization (hpf)).
  2. next, a significant AV conduction delay develops during cardiac chamber formation (36–48 hpf)
  3. as the heart loops and develops ventricular trabeculations (72–96 hpf), an immature fast conduction network develops within the ventricle
  4. finally, this fast conduction network fully matures to an apexto-base activation pattern when the ventricular apex has

formed.