Causally upstream of, negative effect: Difference between revisions

Revision as of 09:14, 8 February 2023

This relation is used in GO-CAMs but not in standard annotation extensions.
This relation is intended to represent a negative causal effect of on activity on another, where the mechanism is not known.
The 'causally upstream of, negative effect' relation is used to relate two GO Molecular Functions when:
- the mechanism that relates the upstream molecular function to the downstream molecular function is not understood
- the upstream molecular function occurs before the downstream molecular function
- the upstream molecular function has a negative effect on the downstream molecular function

What to capture
- Relationships between molecular functions when a negative effect has been demonstrated but the mechanism is not known.
What not to capture
- Relationships where the mechanism is known. These should be represented by other relationships.

This relation is not used in the ontology.

Last reviewed: October 31, 2022 David

@@ Line 14: / Line 14: @@
 == Examples ==
-* mRNA decapping enzymes generally act on messages that repress translation and target them to P bodies for degradation. This is part of normal mRNA turnover in the cell and is not specific to individual RNAs. This process would be causally upstream and have a negative effect on the functions of the proteins encoded by the RNAs. [https://pubmed.ncbi.nlm.nih.gov/16179257/ reference link]
+* TBD
-** [http://noctua.geneontology.org/editor/graph/gomodel:635b1e3e00002476 GO-CAM example]
 == Ontology Usage Guidelines ==